Antibody Structure and Function

Wentworth P, Jr, Janda KD. Catalytic antibodies structure and function. Cell Biochem. Biophys. 2001 35(l) 63-87. 

Anonymous. Antibodies Structure and function. In Goldsby RA, Kindt TH, Obsborne BA, Kuby J, eds. Immunology. New York, Freeman, 2003 76-102. 

Electron Paramagnetic Resonance Spectroscopy Studies of Immobilized Monoclonal Antibody Structure and Function... 

FIGURE 7.1(c) Antibody isotypes. Description of various antibody isotype structures and functions. 

Purification of a protein is usually only a prelude to a detailed biochemical dissection of its structure and function. What is it that makes one protein an enzyme, another a hormone, another a structural protein, and still another an antibody How do they differ chemically The most obvious distinctions are structural, and these distinctions can be approached at every level of structure defined in Figure 3-16. 

Smith, S. 1976. Structural and functional relationships of fatty acid synthetases from various tissues and species. In Immunochemistry of Enzymes and Their Antibodies. M.G.J. Salton, (Editor). John Wiley Sons, New York, pp. 125-146. 

Proteins are the most abundant of cellular components. They include enzymes, antibodies, hormones, transport molecules, and even components for the cytoskeleton of the cell itself. Proteins are also informational macromolecules, the ultimate heirs of the genetic information encoded in the sequence of nucleotide bases within the chromosomes. Structurally and functionally, they are the most diverse and dynamic of molecules and play key roles in nearly every biological process. Proteins are complex macromolecules with exquisite specificity each is a specialized player in the orchestrated activity of the cell. Together they tear down... 

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