Antiallergic action

Side effects are also based on different facet of action (or side effects unrelated to its pharmacological or therapeutic effect). All antihistaminics except few newer compounds e.g. astemizole, terfenadine etc. cause sedation which is unrelated to its therapeutic action i.e. antiallergic action. 

H. Kakegawa, H, Matsumoto, and T. Satoh. Inhibitory effects of some natural products on ihe activation of hyaluronidase and ihdr antiallergic actions, Cheat. Pham. BulL 4ft 1439 (1992). 

There are other compounds in the literature which seem to have a potentially useful blend of bronchodilator and antiallergy action. Compound IX, having a cromolyn-type structure, is effective in the passive cutaneous anaphylaxis test in rats as well as in the histamine aerosol test in guinea pigs (22). It has less cardiovascular effects than theophylline but causes some CNS stimulation. Compound X is a recent compound which in animals appears to be more potent than theophylline in its bronchodilator/antiallergic actions and also appears to have greater broncho-selectivity (23, 24). 

Research in respiratory disease at Mead Johnson has centered on heterocyclic molecules having a mixture of bronchodilator and antiallergic actions. One of these, an imidazopurinone (compound XI), recently emerged with particularly interesting pharmacologic features. Illustrated in Figure 6 are dose-response curves for intraduodenally administered compound XI in three appropriate tests in rats. 

Citrus fruits is used for aromatic stomachic, diaphoresis, expectorans, a bath charges as crude drug and folk medicine from ancient times in China and Japan. Agents with biological activities such as inhibitory action of intestine exercise and antiallergic action may be involved. 

In many countries, glucocorticosteroids are administered as first drug because of their well-known antiallergic effects. However, the onset of action of corticosteroids takes at... 

Mechanism of Action An antiasthmatic and antiallergic agent that prevents mast cell release of histamine, leukotrienes, and slow-reacting substances of anaphylaxis by inhibiting degranulation after contact with antigens. Therapeutic Effect Helps prevent symptoms of asthma, allergic rhinitis, mastocytosis, and exercise-induced bron-chospasm. 

Mechanism of Action An antiallergic agent that selectively antagonizes H, receptor Therapeutic Effect Blocks histamine-associated symptoms of seasonal allergic conjunctivitis. 

From the variety of experimental studies it becomes obvious that mucosal administration is a powerful tool for modulating immune responses. Apart from the importance to test the effectiveness and the mechanisms of action of any allergen of interest as a potential antiallergic agent or tolerogen in animal models, prophylactic treatment strategies could be of interest in patients with a known risk to develop allergy. 

Repirinast is an antiallergic prodrug whose active metabolite has a stabilizing action on mast cells that resembles that of sodium cromoglicate (1). 

Tranilast is an orally active antiallergic agent. It may have a similar mechanism of action to that of cromoglicate. 

The chromone group (e.g. sodium cromoglycate and nedocromil) are important antiallergic and antiinflammatory drugs, as well as antiasthmics and other uses, though their mode of action is imperfecfly understood. 

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