Anti-neutrophil cytoplasmic antibody

Akamizu T, Ozaki S, Hiratani H, Uesugi H, Sobajima J, Hataya Y, Kanamoto N, Saijo M, Hattori Y, Moriyama K, Ohmori K, Nakao K. Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA) possible involvement of complement in granulocyte cytotoxicity. Clin Exp Immunol 2002 127(l) 92-8. 

It is well recognized that antithyroid drugs, and especially propylthiouracil, can be associated with development of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis, often manifesting as renal disease. Atypical presentations, with pyoderma gangrenosum (49) and progressive bilateral sensorineural hearing loss (50), have been described in separate case reports of subjects taking propylthiouracil. 

Nikolova M., Liubomirova M, Iliev A, Krasteva R, Andreev E, Radenkova J, Minkova V, Djerassi R, Kiperova B, Vlahov ID. Clinical significance of antinuclear antibodies, anti-neutrophil cytoplasmic antibodies and anticardiolipin antibodies in heroin abusers. Isr Med Assoc J 2002 4 (11 Suppl) 908-910. 

Knowledge regarding renal injury and the development of anti-neutrophil cytoplasmic antibody (ANCA) positivity associated with silica exposure is rudimentary being hmited to epidemiological observations. Moreover, information about the health significance of the occupational exposure to other silicon containing compounds apart from silica and crystalline sihcates is lacking. 

ABCD amphotericin B colloidal dispersion ANCA anti-neutrophil cytoplasmic antibody... 

A.J. George and C.D. Pusey, (2001). Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize re-... 

Ig = immunoglobulins GN = glomerulonephritis, GBM = glomerular basement membrane, ANCA = anti-neutrophil cytoplasmic antibodies. Adapted from [25],... 

ANCA anti-neutrophil cytoplasmic antibodies rIFN-a recombinant interferon alpha, rIL-2 recombinant interleukin-2. 

In 9 of 11 patients with silica exposure and renal involvement with systemic vasculitis, Chevalier et al. (working in Angers) found various antibodies indicative of autoimmunity, such as MPO-anti-neutrophil cytoplasmic antibodies (ANCA) and ANA at low titers, with anti-RO/Sjogren s syndrome-A in two patients, but without anti-double-stranded DNA (dsDNA) (Conrad et al. 1997). 

Hypersensitivity vasculitis induced by drags is another manifestation of a type III response. Drags involved include some p-lactams, particularly, amoxicillin and cephalexin, cotrimoxazole, NSAIDs, monoclonal antibodies, and chemotherapeutic drags such as tamoxifen and erlotinib. A proportion of small-vessel vasculitis patients have anti-neutrophil cytoplasmic antibodies. Although there is evidence of a pathogenic role for these antibodies and they are used as a diagnostic marker, operative mechanisms underlying this hypersensitivity state are still far from established. 

De Lange TE, Simsek S, Kramer MH, Nanayakkara PWB. A case of cocaine-induced panhypopituitarism with human neutrophil elastase-speciftc anti-neutrophil cytoplasmic antibodies. Eur J Endocrinol 2009 160 499-502. 

Immunologic A 50-year-old woman taking hydralazine for hypertension developed alveolar hemorrhage and anti-neutrophil cytoplasmic antibody (ANCA)-positive pauci-immune glomerulonephritis despite the absence of full criteria for drug-induced... 

Walsh M, Chaudhry A, Jayne D. Longterm follow-up of relapsing/refractory anti-neutrophil cytoplasm antibody associated vascuhtis treated with the lymphocyte depleting antibody alemtuzumab (CAM-PATH-IH). Ann Rheum Dis 2008 67(9) 1322-7. 

Stassen PM, Derks RP, Kallenberg CG, Stegeman CA. Thiopurinemethyltransfer-ase (TPMT) genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis relation to azathioprine maintenance treatment and adverse effects. Ann Rheum Dis 2009 68(5) 758-9. 

Gaudin PB, Askin 143, Falk RJ, et al. The pathologic spectrum of pulmonary lesions in patients with anti-neutrophil cytoplasmic antibodies specific for anti-proteinase 3 and anti-myeloperoxidase. Am J Clin Path 1995 104 7-16. 

Kain R, Matsui K, Exner M, et al. A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 1995 181 585-597. Savage CO, Williams JM. Anti endothelial cell antibodies in vasculitis. J Am Soc Nephrol 2007 18 2424-2426. 

Mulder AH, Stegeman CA, Kallenberg CG, et al. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener s granulomatosis a predominant role for the IgG3 subclass of ANCA. CUn Exp Immunol 1995 101 227-232. 

Porges AJ, Redecha PB, Kimberly WT, et al. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma Rlla. J Immunol 1994 153(3) 1271-1280. 

Booth A, Harper L, Hammad T, et al. Prospective study of TNFalpha blockade with infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol 2004 15(3) 717-721. 

Richter C, Schnabel A, Csemok E, et al. Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vascuhtis with high-dose intravenous immunoglobulin. Chn Exp Immunol 1995 101(l) 2-7. 

Little MA, Bhangal G, Smyth CL, et al. Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis. J Am Soc Nephrol 2006 17 160-169. 

Moosig E, Csernok E, Kumanovics G, et al. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). Clin Exp Immunol 2000 122 499 503. 

Ruth AJ, Kitching AR, Kwan RY, et al. Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J Am Soc Nephrol 2006 17 1940-1949. 

Mansi lA, Opran A, Sondhi D, et al. Microscopic polyangiitis presenting as idiopathic pulmonary fibrosis is anti-neutrophilic cytoplasmic antibody testing indicated Am J Med Sci 2001 321 201-202. 

Urinary tract A case report was published on anti-neutrophil cytoplasmic antibody (ANCA)-positive pauci-immxme glomerulonephritis during febuxostat treatment. A 63-year-old African started treatment with febuxostat (dose not reported) because he had a history of chronic asymptomatic hyperuricemia which was not adequately controlled by allopurinol therapy. After 6 months of febuxostat therapy he developed AKI, characterised by acute renal failure, nephritic syndrome, proteinuria, microscopic haematuria and aseptic leukocyturia. Within 48 h after discontinuation of febuxostat, serum creatinine levels improved, although nephritic syndrome remained. ANCA-positive pauci-immune glomerulonephritis was confirmed by renal biopsy revealing diffuse crescentic necrotizing glomerulonephritis [60 ]. 

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