Anti-microbial preservatives

Anti-microbial, preservative, also used as a chemical intermediate. 

Case 1 The amount of anti-microbial preservatives in the cosmetic formulation has not been calculated properly in the product design, and the cosmetic is not preserved well enough. This is an example of a safety problem the mamrfacturer must modify the formulation, and all the batches that were put onto the market will have to be withdrawn. 

Case 2 The product should contain a specific amount of anti-microbial preservatives (according to its formulation), but due to a production failure several batches were produced without the correct dose. This is an example of a quality problem the cosmetic product is well formulated but the operator in charge made a mistake and added an insufficient amount of preservatives in several batches. Only the affected batches will have to be withdrawn from the market. 

Product A non-metal lie, organic chemical, COSAN S is a highly effective anti-microbial preservative for water systems including adhesives, dispersed colors, protein colloids, and resin emulsions. 

Utilising the usual levels of anti-microbials for cleansing products with normal user instructions of three minutes or longer contact time can achieve positive claims of anti-bacterial for Myavert C based enzyme preservation system without the stinging associated with alcohol. Table 1 gives the plate kill speed data for a face masque where the preservative also becomes a positive attribute. 

The table 1 summarises the challenge test data using Myavert C 5 part enzyme based preservation in a face mask 1 including speed of kill test to justify positive marketing claims for the anti-microbial system used in the product. Table 2 uses conventional chemical anti-microbials for a foot product at much higher levels than would be allowed for face application yet the speed of kill of the enzyme system is superior yet much more mild. 

Antioxidants and chelating agents. Antioxidants inhibit the oxidative reactions in oils, fats and waxes that lead to rancidity, with its distinctively unpleasant smell. Due to their reducing properties, antioxidants only exhibit weak anti-microbial efficacy. However, they can enhance the efficacy of certain preservatives, such as Bronopol [II, 17.14.], German 115 [II, 3.4.7.], Glydant [II, 3.4.9.] and Kathon CG [II, 15.3.], allowing a reduction of the... 

Preservation of textile materials by anti-microbial modification... 

Creosote and chromated copper arsenate (CCA) have been widely used as preservatives for antibacterial treatment of wood. In spite of their excellence in this property, they have some drawbacks in toxicity. Therefore, less toxic and environmentally-benign chemicals are expected to be used. Quaternary alkylammonium salts are, thus, one of the candidates for the anti-microbial treatment of wood. In this study of wood-inorganic composites, trimethoxysilylpropyldimethyloctadecyl ammonium chloride (TMSAC), shown below, was used as a property enhancer to add an anti-bacterial property to wood (Tanno, 1997). 

There is a restriction on the maximum authorized level of zinc 4-hydroxybenzene sulphonate in deodorants and antiperspirants estabUshed in the EU legislation (European Commission, Council Directive 76/768/CEE, 1976, Annex III), also for zinc pheno-sulphonate, dichlorophene and other substances used in deodorants. Triclosan and other anti-microbial treated in Chapter 5 are considered as preservatives by the EU legislation and their maximum authorized level is restricted (Annex VI) however, they have an additional anti-microbial function for deodorant users. 

DOWICIL 75 Preservative is the designation for l-(3-chloro-allyl)-3,5,7-triaza-l-azoniaadamantane chloride combined with a stabilizer (sodium bicarbonate). It is designed to provide highly effective anti-microbial activity in aqueous formulations, including adhesives, paints, construction materials, latexes, and detergents, to name just a few. 

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