Cancer chemoprevention flavonoids

Jang, D.S. et al., Potential cancer chemopreventive flavonoids from the stems of Tephrosia toxicaria. Journal of Natural Products, 66, 1166, 2003. 

Walle T. 2007. Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass Semin Cancer Biol 17 354-362. 

Jiang, C., Agarwal, R., and Lu, J., Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochemical Biophysical Rese. Commun., 276, 371-378, 2000. 

Ramos S. 2007. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18(7)427 142. 

In addition to their possible prooxidant activity (see above) polyphenols and flavonoids may influence cancer cells via their antioxidant properties. Recently, Jang et al. [219] studied cancer chemopreventive activity of resveratrol, a natural polyphenolic compound derived from grapes (Chapter 29). These authors showed that resveratrol inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. Flavonoids silymarin and silibinin also exhibited antitumor-promoting effects at the stage I tumor promotion in mouse skin [220] and manifested antiproliferative effects in rat prostate cancer cells [221]. 

Roles of Polyphenols, Flavonoids, and Oligomeric Proanthocyanidins in Cancer Chemoprevention... 

Several methods exist for the treatment of cancer in modem medicine. These include chemotherapy, radiotherapy, and surgery most cancer chemotherapeutants severely affect the host normal cells. Hence, the use of natural products now has been contemplated of exceptional value in the control of cancer. Plant-derived natural products such as flavonoids, terpenes, and alkaloids have received considerable attention in recent years due to their diverse pharmacological properties including cytotoxic and cancer chemopreventive effects. 

Ahmad N, Gab H, Javed S, Agarwal R. Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. Biochem Biophys Res Commiin 1998 247 294-301. 

Chen, A. Y. and Y. C. Chen. 2013. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138(4) 2099-2107. 

Many of the hop s constituents, including valerianic acid, have a sedative effect, and it is now used to treat insomnia, restlessness, and anxiety. Its bitter principals, humulon and lupulon, are gastrointestinal stimulants used to treat indigestion and loss of appetite. These bitter acids also have antibacterial and antimicrobial properties. The hop is believed to contain chemicals that promote menstruation, and certain flavonoids have shown potential chemopreventive activity against breast and ovarian cancer. 

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