Androgens antiandrogens

SARMs are AR ligands that display tissue-specific androgenic/antiandrogenic activities. 

Testing consisted of in vitro determination of androgenic/antiandrogenic activity on mouse mammary carcinoma Shionogi cells and in vivo determination of systemic antiandrogenic activity of immature male rats. A summary of these testing results is provided in Table 1 where ... 

Cyproterone acetate (CPA) is a progestational antiandrogen that blocks the androgen receptors. It is combined with ethinyl estradiol in an oral contraceptive formulation, which is indicated in female acne patients with a high level of seborrhea, therapy resistant papulo-pustular acne or acne conglobata not responding to other treatments. 

Spironolactone is an antiandrogen which blocks androgen-receptors, alters steroidogenesis by adrenals and gonads and inhibits 5-a reductase. In doses of 100-200 mg daily it reduces sebum production and improves inflammatory acne in women. During treatment, birth control measures are required due to the risk of male fetus feminization. 

The antiandrogens block androgen receptors to inhibit the action of testosterone and dihydrotestosterone in prostate... 

Androgen ablation with a luteinizing hormone-releasing hormone (LHRH) agonist plus an antiandrogen should be used prior to radiation therapy for patients with locally advanced prostate cancer to improve outcomes over radiation therapy alone. 

Antiandrogens inhibit the formation of the DHT-receptor complex and thereby interfere with androgen-mediated action at the cellular level.22 Megestrol acetate, a progestational agent, also is available and has antiandrogen actions.21 Finally, the conversion of testosterone to DHT may be inhibited by 5-a-reductase inhibitors.6... 

---