Progestational agents

The orally active progestational agent 17a-ethynyltestosterone (56) was subsequently obtained by Oppenauer Oxidation. Similarly ethynyla-tion of 3-ethoxyandrosta-3,5-dien-17-one followed by acid hydrolysis afforded the 17a-ethynyl compound (56). ... 

Antiandrogens inhibit the formation of the DHT-receptor complex and thereby interfere with androgen-mediated action at the cellular level.22 Megestrol acetate, a progestational agent, also is available and has antiandrogen actions.21 Finally, the conversion of testosterone to DHT may be inhibited by 5-a-reductase inhibitors.6... 

Progesterone may be linked to breast cancer etiology also, there is concern regarding the safety of progestational agents in women with preexisting breast cancer... 

For catamenial epilepsy (seizures just before or during menses) or seizures that occur at the time of ovulation, conventional AEDs should be tried first, but hormonal therapy (progestational agents) may also be effective. Intermittent acetazolamide has also been used. 

The cause of abortion is generally a defective ovum, which progestational agents could not be expected to influence. In addition, progestational agents have uterine relaxant properties that may cause a delay in spontaneous abortion when given to patients with fertilized defective ova. 

Although it is a relatively old drug, Flumedroxone (Demigran ), marketed as a progestative agent, is worthy of attention here. This derivative of 17-hydroxy... 

Unopposed estrogen increases risk of endometrial cancer recommended administration of concurrent progestational agents for nonhysterectomized women... 

The cytologic findings on vaginal smears vary depending on the preparation used. However, with almost all of the combined drugs, a low maturation index is found because of the presence of progestational agents. 

When used alone, estrogen replacement therapy increases the risk of endometrial cancer. This risk can be eliminated by treatment with a progestational agent for up to 14 days a month. However, the oral administration of natural progesterone has associated limitations ... 

The clinical uses of progestational agents are ill-defined, apart from contraception, the menopause and postmenopausal hormone replacement therapy (see above). 

Posttraumatic uterine synechiae (Asherman s syndrome) Progestational agents... 

---