Figures of merit, analytical

Table 8.29 shows the main characteristics of ICP-AES as a fast multi-element technique. Analytical figures of merit for ICP emission spectrometers are... 

The combination of pin printing and sol-gel processing techniques provides a simple method to rapidly fabricate reusable chemical sensor element into arrays that exhibit good analytical figures of merit. This methodology also provides a straightforward means to fabricate reusable sensor arrays for simultaneous multianalyte quantification. 

Table 1 Analytical Figures of Merit and Applications of Low-Pressure Stopped-Flow CL Spectrometry in Routine Analyses... 

Based on the analytical figures of merit of the methods in Table 1, the best precision and selectivity are accomplished by using the decay rate rather than the formation rate or conventional CL-measured parameters such as the peak height or area under the CL curve. Table 2 gives the selectivity factor, expressed as decay-rate and peak-height tolerated concentration ratio, for the CL determination of hydrogen peroxide using SF-CLS. As can be seen, the selectivity factor was quite favorable in most instances. 

Table 4 illustrates the use of the CAR technique to develop CL kinetic-based determinations for various analytes in different fields. As can be seen, the dynamic range, limit of detection, precision, and throughput (—80-100 samples/ h) are all quite good. All determinations are based on the use of the TCPO/ hydrogen peroxide system by exception, that for p-carboline alkaloids uses TCPO and DNPO. A comparison of the analytical figures of merit for these alkaloids reveals that DNPO results in better sensitivity and lower detection limits. However, it also leads to poorer precision as a result of its extremely fast reactions with the analytes. Finally, psychotropic indole derivatives with a chemical structure derived from tryptamines have also been determined, at very low concentrations, by CAR-CLS albeit following derivatization with dansyl chloride. 

Table 4 Analytical Figures of Merit of the CL Kinetic-Based Determination of Drugs and Hallucinogenic Alkaloids Using the CAR Technique... 

Report the analytical figures of merit (i.e. limit of detection, linear range, characteristic concentration) for the magnesium calibration and compare with literature values. 

SOURCE J. M. Mermet and E. Pousse/, /CP Emission Spectrometers Analytical Figures of Merit. Appl. Spectros. /995, 49, 12A. 

Regardless of the type of immobilization, it is now clear that the local environment of the immobilized nucleic acids is a key determinant of their binding activity [5,6]. Optimization of nucleic acid immobilization chemistry can concurrently alter the sensitivity and speed of the particular sensor methodology. Factors such as immobilization density [5,6], interaction with the substrate [7,8] probe nature [2,4,5,9] and sample processing have been demonstrated to have direct effects on the analytical figures of merit. 

Liquid chromatography/mass spectrometry (LC/MS)-based techniques provide unique capabilities for pharmaceutical analysis. LC/MS methods are applicable to a wide range of compounds of pharmaceutical interest, and they feature powerful analytical figures of merit (sensitivity, selectivity, speed of analysis, and cost-effectiveness). These analytical features have continually improved, resulting in easier-to-use and more reliable instruments. These developments coincided with the pharmaceutical industry s focus on describing the collective properties of novel compounds in a rapid, precise, and quantitative way. As a result, the predominant pharmaceutical sample type shifted from nontrace/pure samples to trace mixtures (i.e., protein digests, natural products, automated synthesis, bile, plasma, urine). The results of these developments have been sig-... 

The determination of organic selenium compounds is done preferably by GC coupled to element-or molecule-specific detectors, such as GC-AED or molecular mass spectrometric detection (GC-MS).240 In this case, ICP-MS detection does not yield the improvement in sensitivity otherwise seen, which is due to spectral interferences. Dietz et al.241 have compared the analytical figures of merit of three detector systems for GC (AED, atomic fluorescence spectroscopy (AFS), and ICP-MS), arriving at the conclusion that GC-AED is the most sensitive and most practical... 

Table 15.18 Analytical figures of merit in the determination of alkylmercury compounds by the GLC-MIP system...

Faber, K., Notes on analytical figures of merit for calibration of nth-order data, Anal. Lett., 31, 2269-2278, 1998. 

Faber, K., Lorber, A., and Kowalski, B.R., Analytical figures of merit for tensorial calibration, J. Chemom., 11 419W62, 1997. 

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