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Amycolatopsis orientalis

ANTTBIOTTCS - GLYCOPEPTIDES (DALBAHEPTIDES)] (Vol 2) Amycolatopsis orientalis ATCC 53550... [Pg.52]

As recently as 1970, only about 30 naturally occurring organohalogen compounds were known. It was simply assumed that chloroform, halogenated phenols, chlorinated aromatic compounds called PCBs, and other such substances found in the environment were industrial pollutants. Now, only a third of a century later, the situation js quite different. More than 5000 organohalogen compounds have been found to occur naturally, and tens of thousands more surely exist. From a simple compound like chloromethane to an extremely complex one like vancomycin, a remarkably diverse range of organohalogen compounds exists in plants, bacteria, and animals. Many even have valuable physiological activity. Vancomycin, for instance, is a powerful antibiotic produced by the bacterium Amycolatopsis orientalis and used clinically to treat methicillin-resistant Staphylococcus aureus (MRSA). [Pg.351]

Actinoplanes missouriensis Actinoplanes sp. Dactylosporangium variesporum Nocardia autotrophica Amycolatopsis orientalis Pseudonocardia autotrophica Saccharopolyspora erythrara Saccharopolyspora hirsuta Saccharothrix sp. [Pg.212]

Vancomycin is an antibiotic produced by Streptococcus orientalis and Amycolatopsis orientalis. With the single exception of flavobacterium, it is active only against gram-positive bacteria, particularly staphylococci. Vancomycin is a glycopeptide of molecular weight 1500. It is water soluble and quite stable. [Pg.994]

Two biosynthetic intermediates of the vancomycin glycopeptides, SP-969 (2221) and SP-1134 (2222), are found in cultures of Amycolatopsis mediterranei (2018). This is the first reported isolation of linear biosynthetic intermediates of the vancomycin family. Monodechlorovancomycin 2223 is found for the first time in fermentation broths of Amycolatopsis orientalis (2019). The other monodechlorovancomycin was synthesized for comparison with 2223. [Pg.332]

M.-R. Kula, Screening, overexpression and characterization of an N-acylamino acid racemase from Amycolatopsis orientalis subsp. lurida, Appl. Microbiol. Biotechnol. 2001, 55, 354-361. [Pg.208]

Vancomycin (1, Figures 1.2 and 1.3) is a glycopeptide antibiotic with high activity against Gram-positive bacteria and is particularly renowned for its activity against the feared methicillin-resistant Staphylococcus aureus (MRSA) species [lb]. Vancomycin is produced by Amycolatopsis orientalis, a bacterium originally found in a soil... [Pg.4]

As a matter of fact, vancomycin (82) is produced by Amycolatopsis orientalis [80], it is only mentioned here since the strain was previously called S. orientalis. [Pg.332]

A fermentation process was developed for the production of epothilone B, and the titer of epothilone B was increased by a continuous feed of sodium propionate during fermentation. The inclusion of XAD-16 resin during fermentation to adsorb epothilone B and to carry out volume reduction made the recovery of product very simple (Benigni et al., 2004). A microbial hydroxylation process was developed for the conversion of epothilone B (10) to epothilone F (11) by Amycolatopsis orientalis SC 15847. A bioconversion yield of 37-47 % was obtained when the process was scaled up to 100-250 L. Recently, epothilone B hydroxylase and the ferredoxin gene have been cloned and expressed in Streptomyces rimosus from Amycolatopsis orientalis SC 15847 by our colleagues in Bristol-Myers Squibb. Mutants and variants thereof this cloned enzyme has been used in the hydroxylation of epothilone B to epothilone F to obtain even higher yields of product (Basch et al, 2004). [Pg.324]

Vancomycin was discovered in the 1950s in a soil sample collected in the jungle of Borneo and isolated by Eli Lilly from culture broth of the actinomycete Streptomyces orientalis, which was later named Nocardia orientalis and finally Amycolatopsis orientalis. It was first used in clinics in 1959, and today also teicoplanin (O Fig. 25) is being used clinically. The other gly-copeptides of the vancomycin group such as ristocetin A (O Fig. 26) have too many toxic side effects to be used as a therapeutic. Vancomycin and teicoplanin are among the last antibiotics... [Pg.2573]

UK-69,753 (SMI) was isolated from cultures of Amycolatopsis orientalis [265]. Its structure was determined using UV, FABMS, elemental analysis, H and NMR, acid hydrolysis to give the disaccharide, and X-ray crystallography of the disaccharide unit [266], In vitro assay showed 90 posesscd antibacterial activity, being particularly effective against Clostridium difficile and Treponema hyodysenteriae (MIC = 0.39 pg/ml and 0.78 pg/ml, respectively [266], In vivo, 90 (3.6 or 7.1 mg/kg/day) provided effective treatment of mice colonized with T. hyodysenteriae [266]. [Pg.208]


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Amycolatopsis

Amycolatopsis orientalis [Vancomycin

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