Amphetamine, in urine

AMPHETAMINES. Amphetamines, used in medicine as central nervous system (CNS) stimulants, are among the most commonly abused drugs. Amphetamine itself is chemically di-a-methylphenethyl-amine, the most common commercial name being Benzedrine, nicknamed "Bennie." Other commonly encountered amphetamines in urine... [Pg.539]

L-Methamphetamine is biotransformed in a similar manner to the D-isomer but at a slower rate. Following a 13.7-mg oral dose, the 24-h urine contained an average of 34% of the dose as L-methamphetamine and 1.7% of the dose as L-amphetamine.3 Oyler et al.13 described the appearance of methamphetamine and amphetamine in urine after volunteers (n = 8) ingested 4 X 10-mg doses of methamphetamine hydrochloride daily for 7 days followed by 4 X 20 mg daily several weeks later. Parent and metabolite were generally detected in the first or second void post dose in a concentration range of 82 to 1827 and 12 to 180 ng/ml, respectively. Peak methamphetamine urine concentrations (1871 to 6004 ng/ml) occurred within 1.5 to 60 h after a single dose. [Pg.29]

Yamamoto, Y., Yamamoto, K., Comparison of Enzyme Multiplied Immunoassay Technique and High Performance Liquid Chromatography in Determination of Amphetamine in Urine, Nippon Floigaku Zasshi, 34,158,1980. [Pg.118]

T. Niwaguchi, Y. Kanda, T. Kishi, and T. Inoue, Determination of d-meth-amphetamine in urine after administration of d- or d,i-methamphetamine to rats by radioimmunoassay using optically sensitive antiserum, /. Forensic Set., 27 592-597 (1982). [Pg.62]

Bogusz et al. [68] reported the LC-APCI-MS analysis of sixteen phenethylamines after SPE. Subsequently, optimization of the mobile-phase composition for the LC-ESI-MS analysis of methylamphetamine and related compounds was described [69]. Methanol in the mobile phase resulted in a slightly higher abundance of the [M+H]. Formic acid was preferred over other additives. Microporous ultrafiltration was used in the sample pretreatment of urine samples. The intra-assay and inter-assay precision and accuracy in the 100-1000 ng/ml range were 2.3-6.3%, 0.8-5.9%, and 1.6-6%, respectively, for amphetamine in urine. [Pg.345]

The following method was outlined from the paper of Heaton and Blumberg57. They used the popular solvent system, CHCl3-acetone (9 1). (See Table III for 7 references using this system.) They have successfully employed the method for detection of barbiturates, narcotics, and amphetamines in urine of patients receiving psychotropic drugs. The procedure can be used for pharmaceutical dosage forms. [Pg.356]

Screening for amphetamines A highly sensitive screening strip for methyl amphetamine in urine may be prepared using the Simon reagent. A silica gel TLC plate is sprayed with equal volumes of 2% sodium nitroprusside and 5% aqueous sodium carbonate solution, and dried for 3 h at 110°C. A strip is cut from the plate to use in the test. [Pg.4543]

Sun J, Xu X, Wang C, You T (2008) Analysis of amphetamines in urine with liquid-liquid extraction by capillary electrophoresis with simultaneous electrochemical and electrochemiluminescence detection. Electrophoresis 29(19) 3999-4007. doi 10.1002/ elps.200700875... [Pg.100]

Routine Method for the Detection and Quantitation of Amphetamine in Urine... [Pg.229]

Marais AAS, Laurens JB (2009) Rapid GC-MS confirmation of amphetamines in urine by extractive acylation. Forensic Sci Int 183 78-86... [Pg.1236]

Centini, F., et al. "Quantitative and Qualitative Analysis of MDMA, MDEA, MA and Amphetamine in Urine by Headsjjace/Solid Phase Micro-extraction (SPME) and GC/MS." Forensic Science International 83 (19%), 161-166. [Pg.130]

Sources (1) Liau, A. S., et al. "Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by beta-cyclodextrine modified capillary electrophoresis a complementary method to GC-MS." Forensic Science International, 134 2003,17-24. (2) Cheng, W.-C., et al. "Enantiomeric Separation of Methamphetamine and Related Analogs by Capillary Zone Electrophoresis Intelligence Study in Routine Methamphetamine Seizures." Journal of Forensic Sciences, 47 2002,1248-1252. (3) Al-Dirbashi, O., et al. "Achiral and Chiral Quantification of Methamphetamine and Amphetamine in Urine by Semi-micro Column High Performance Liquid Chromatography and Fluorescence Detection." Journal of Forensic Sciences, 45 2000,708-714. [Pg.326]

Heaton, A.M., and Blumberg, A.G. (1969) Thin-layer chromatographic detection of barbiturates, narcotics, and amphetamines in urine of patients receiving psychotropic drugs. Journal of Chromatography, 41,367-370. Ono, M., and Engelke, B.F. (1969) Procedures for assured identification of morphine, dihydromorphinone, codeine, norcodeine, methadone, quinine, methamphetamine, etc., in human urine. Bulletin in Narcotics, 21, 31-40. [Pg.28]

Beckett,A.H.,and Rowland, M. (1965) Determination and identification of amphetamine in urine. Journal of Pharmacy and Pharmacology, 17, 59-60. [Pg.29]

Colbert, D.L., Gallacher, G., and Mainwaring-Burton, R.W. (1985) Singlereagent polarization fluoroimmunoassay for amphetamine in urine. Clinical Chemistry, 31,1193-1195. [Pg.35]

Turner, G.J., Colbert, D.L., and Chowdry, B.Z. (1991) A broad spectrum immunoassay using fluorescence polarization for the detection of amphetamines in urine. Annals of Clinical Biochemistry, 28(Pt 6), 588-594. [Pg.35]

Thurman, E.M., Pedersen, M.J., Stout, R.L., and Martin, T. (19920 Distinguishing sympathomimetic amines from amphetamine and meth-amphetamine in urine by gas chromatography/mass spectrometry./ouma/ of Analytical Toxicology, 16,19-27. [Pg.133]

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