Methyl amphetamine

Garden City, NY, Medical Examination Publishing, 1981 Snyder SH, Faillace L 2,3-Dimethoxy-4-methyl-amphetamine (STP) a new hallucinogenic drug. Science 1388 669-670, 1967 Spielewoy C, Markou A Withdrawal from chronic phencyclidine treatment induces long-lasting depression in brain reward function. Neuropsychopharmacology 28 1106-1116,2003... 

Commissaris, R. L., Lyness, W. H., Moore, M. E., and Rech, R. H. (1980) Enhancement of the behavioral effects of 2,5-dimethoxy-4-methyl-amphetamine (DOM) by pretreatment with p-chlorophenylalanine. Pharmacol. Biochem. Behav., 13 605-608. 

Lise of N-methyl-formamide in place of formamide will give the corresponding N-methyl-amphetamine which is nicer. 

The formula on the next page is designed to methylate amphetamines, which are usually more stimulating and pleasant than the non-methylated versions. This formula is also described for the p-methoxy derivative and it too may be used to methylate most phenethylamines without substantive modification. They were taken from JMC, 15, 214. The alcohol p-anisyl is replaced with trimethoxybenzyl, you get mescaline. 

Pseudoephedrine. Same as above, except that it is better suited to the reduction to methyl-amphetamine. 

Gas Chromatography. System GA—benzphetamine RI 1855, amphetamine RI 1123, methylamphetamine RI 1176 system GB—benzphetamine RI 1895, amphetamine RI 1134, methyl-amphetamine RI 1200 system GC—benzphetamine RI 2172, amphetamine RI 1536, methylamphetamine RI 1722 system GF—benzphetamine RI 2050, amphetamine RI 1315, methylamphetamine RI 1335. 

C10H14CIN p-chloro-N-methyl amphetamine 1199-85-5 525.15 46.306 2 20026 C10H14O 2,5-dimethyl-6-ethylphenol. .. 500.00 6.804 2... 

The. second class of hallucinogens includes MDA and MDMA (ec.stasy), referred to as the methylated amphetamines. As the name suggests, these drugs are structurally related to amphetamine (as is mescaline). MDA and MDMA produce alterations in mood and consciousness with little or no sensory change. They arc thought to act like amphetamine and cocaine on dopamine, norepinephrine, and serotonin synapses (Morton, 2005). 

Morton, 2005). DOM (2,5-dimcthox) -4 methyl-amphetamine) not only resembles mescaline in structure but also produces. similar effects, including visual hallucinadons. 

Methylated amphetamines were developed in the early 1900s but attracted little attention until relatively recendy. For example, MDMA... 

Hallucinogens may be divided into four classes serotonergic hallucinogens, methylated amphetamines, anticholinergic hallucinogens, and dissociative anesthetics. 

Methylated amphetamines include drugs such as MDA and MDMA (ecstasy). These drugs are sympathomimetic and produce many other effects similar to LSD but generally do not produce visual hallucinations. 

Methylated amphetamines A class of drugs including MDA and MDMA (ecstasy) (Chapter 12). 

Monoamine oxidase inhibitors and many pharmacological agents are synergistic, sometimes resulting in a hypertensive crisis. The agents with which the MAOIs may be synergistic include amphetamine, dextroamphetamine, methyl amphetamine, ephedrine, procaine preparations (which usually contain norepinephrine), epinephrine, methyldopa, and phenylpropanolamine (over-the-counter cold preparations). 

The phenylalkylamines mescaline, 2,5-dimethoxy-4-methyl amphetamine (DOM) and 3,4-dimethoxyphenylethylamine had no effects on caeruloplasmin — they were neither substrates nor did they modify the oxidation of known substrates. In other studies on the substrate specificity of caeruloplasmin it was noted that, in addition to being a substrate, 3-hydroxy-4-methoxyphenylethylamine accelerated the oxidation of both noradrenaline and 5-HT. Since demethylated metabolites of mescaline have been isolated by Musacchio and Goldstein (1967) from rats given this drug, it is possible that it is these metabolites which are the chemical species actually responsible for the observed central effects. In such a situation there should be a correlation between the central effects of the compound administered and the interaction of its demethylated metabolite with caeruloplasmin, but there would be no correlation between the central effects of the compounds and their effects on the enzyme. This point requires further experimental study. 

Idanpaan-Heikkila, J. E. and McIsaac, W. M. (1970) 2,5-Dimethoxy-4-methyl-amphetamine. Tissue distribution- and, neurochemical action. Biochem. Pharmacol., 19, 935-937. 

Snyder, S. H., Faillace, L. and Hollister, L. (1967) 2,5-Dimethoxy-4-methyl-amphetamine (STP). A new hallucinogenic drug. Science, 158,669-670. 

Amphetamine type of stimulants Methyl-amphetamine, 2, 5-dimethoxy-4-methyl amphetamine, methylene dioxy amphetamine Adsorption Corasil II Gradient system of ethanol/dioxan/ cyclohexylamine in hexane... 

All three isomers of monomethylamphetamine have also been looked at in man. The ortho- and meta-isomers, 2-methyl- (and 3-methyl-) amphetamine are weak anorexics. At doses of up to 150 milligrams orally, there were signs of stimulation noted Q talkativeness and loss of appetite. The para-isomer, 4-methyl-amphetamine or Aptrol, is more potent. At 75 milligrams (orally, in man) there is clear adrenergic... 

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