Amines => amides

The hydroxyl groups on glycols undergo the usual alcohol chemistry giving a wide variety of possible derivatives. Hydroxyls can be converted to aldehydes, alkyl hahdes, amides, amines, a2ides, carboxyUc acids, ethers, mercaptans, nitrate esters, nitriles, nitrite esters, organic esters, peroxides, phosphate esters, and sulfate esters (6,7). 

Amines with Amide Linka.ges, Representatives of this group are prepared from carboxyUc acids and di- and polyamines. The amide linkage connects the amine to relatively inexpensive hydrophobes. Eormulas for typical amide amines are as foUow ... 

Addition compounds form with those organics that contain a donor atom, eg, ketonic oxygen, nitrogen, and sulfur. Thus, adducts form with amides, amines, and A/-heterocycles, as well as acid chlorides and ethers. Addition compounds also form with a number of inorganic compounds, eg, POCl (6,120). In many cases, the addition compounds are dimeric, eg, with ethyl acetate, in titanium tetrachloride-rich systems. By using ammonia, a series of amidodichlorides, Ti(NH2) Cl4, is formed (133). 

DPTS-di-pentamethylene thiuram tetrasulfide TDD-thiodiazoIe derivative NC-fatty acid amide amine B-18-special curative DOTG-dior-tho-tolyl guanidine peroxide 14/40-dicumyI peroxide TAC-triallyl cyanurate. 

Sulfoxides, Amides, Amine Oxides and Related Ligands... 

Schwarz, D.P., Sheraian, J.T. "Improved N-Chloiinatkn ProceduR for Detecting Amides, Amines and Related Compounds on lliin-Layer Chtomatagrams", J. Chmmatogr. 19K1, 2 206-208. 

Amides Amines Esters Ethers, epxoides Halides, sulfonates... 

Examples of the protection of alkynes, carboxylic acids, alcohols, phenols, aldehydes, amides, amines, esters, ketones, and alkenes are also indexed on p. xvii. Section (designated with an A 15A, 30A, etc.) with protecting group reactions are located at the end of pertinent chapters. 

Cleavage of all the linkers described above provide a functional group (carboxylic acid, amide, amine, etc) at the anchoring position. Silyl-based handles 71,72, and 73 as well as germanium-based handle 74 insert a C-H bond at the anchoring position and are referred to as traceless (Fig. 15) [82-... 

The synthesis of nitriles from halides is valuable in medicinal chemistry because nitriles are flexible building blocks readily converted into carboxylic acids, amides, amines, or a variety of heterocycles, e. g. thiazoles, oxazolidones, triazoles, and tetrazoles. The importance of the tetrazole group in medicinal chemistry is easily understood if we consider that it is the most commonly used bioisostere of the carboxyl group. 

Importantly, unmodified PAMAM and PPI dendrimers have functional groups within their interior as well as on their exterior. Specifically, PAMAM dendrimer interiors contain both tertiary and secondary (amide) amines, and both of these are ligands for many metals [19,82,83,87,89]. For example, Turro et al. [87, 89] investigated the binding of Cu + ions to integer and half-integer PAMAM dendrimers. Their EPR results indicated that Cu + can bind to both exterior acid and amine groups, as well as to interior tertiary amines and amides. Similarly, PPI dendrimers have interior tertiary amines and are also able to bind metal ions, such as Cu +, Zn +, and Ni + within their interior [90,100]. 

Uses Solvent for liquids, gases, vinyl resins, wire enamels polyacrylic fibers gas carrier catalyst in carboxylation reactions organic synthesis (manufacture of aldehydes, amides, amines, esters, heterocyclics). 

High bulk-densiry NGu and recrystn of NGu from aq soln contg a little HAc and a little of a deriv of NGu such as hyarazone, hyarazide, amide, amine, sulfonamide, sulfate) 20a) Cond-ChemDicr (1961), 805-R (NGu) 21) L.D. Sadwin, Science 143(3611), 1164, 1169(1964) CA 60, 14188(1964) (Explosive welding with NGu)... 

Methacrylonitrile (1) differs from 2 only in that it has a methyl (CH3) group on the a-carbon atom. It too is widely used in the preparation of homopolymers and copolymers, elastomers, and plastics and as a chemical intermediate in the preparation of acids, amides, amines, esters, and other nitriles. In a study conducted by the NTP in which 1 was administered orally to mice for 2 years, there was no evidence that it caused cancer, although other less serious toxic effects were noted [27]. Because 1 does not cause cancer, but undergoes many of the same nucleophilic addition reactions as 2 at the (3-carbon, it is sometimes used as a safer commercial replacement for 2, such as in the manufacture of an acrylonitrile-butadiene-styrene-like polymer that provides improved barrier properties to gases such as carbon dioxide in carbonated beverage containers. 

The Direct Conversion of Aldehydes to Amides Amination or Amino-de-hydrogenation... 

Table 20 Adduct Formation Constants of [VO(acac)2] (Equation 36) with Amides, Amines, Sulfoxides and Pyridine Derivatives... 

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