Amide , amines from occurrence

With substituted halogenobenzenes, the amide ion might be expected to add preferentially to one or other end of the triple bond and so lead to rearranged amines or mixtures of amines. The occurrence of such cine substitution has obvious attractions for the synthetic chemist in providing useful routes to various amines which might otherwise be difficult to obtain. An example is provided by the synthesis of 2-amino-4-methoxybiphenyl from 3-bromo-4-methoxybi-phenyl (reaction 61). A similar rearrangement is exploited in a recent synthesis of the aporphine alkaloid, laureline. ... 

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