Allergy clinical manifestations

Hidvegi, E., Cserhati, E., Kereki, E., Savilahti, E., and Arato, A. 2002. Serum immunoglobulin E, IgA, and IgG antibodies to different cow s milk proteins in children with cow s milk allergy Association with prognosis and clinical manifestations. Pediatr Allergy Immunol 13 255-261. 

Adel-Patient, K., Nahori, M.A., Proust, B. et al. 2003. Elicitation of allergic reaction in P-lactoglobulin sensitised Balb/c mice Biochemical and clinical manifestations differ depending on the structure of the BLG used for the challenge. Clin Exp Allergy 33 376-385. 

The data pertain to the allergens that have been shown to bind IgE in sera from at least three patients with clinical manifestations of allergy to the food from which the allergen originated (Jenkins et al. 2007). 

II. PREVALENCE, MECHANISMS, AND CLINICAL MANIFESTATIONS OF FOOD ALLERGY... 

Pleskow WW, Stevenson DD, Mathison DA, Simon RA, Schatz M, Zeiger RS. Aspirin desensitization in aspirin-sensitive asthmatic patients clinical manifestations and characterization of the refractory period. J Allergy Clin Immunol 1982 69(1 Pt 1) 11-19. 

In 31 patients with Rhus allergy over a 10-year period the clinical manifestations included maculopapular eruptions (65%), erythema multiforme (32%), erythroderma (19%) pustules, purpura, wheals, and blisters (5). All the patients had generalized or localized pruritus, and other symptoms included gastrointestinal problems (32%), fever (26%), chills, and headache. Many developed a leukocytosis (70%) with neutrophilia (88%), and some had toxic effects on the liver or kidneys. All responded to glucocorticoids or antihistamines. 

In one case of tubulointerstitial nephritis and nephrotic syndrome induced by Triazolam, a sleep inducer numerous eosinophils [85] were found to infiltrate glomeruli and interstitium suggesting that eosinophils may be pathogenic in this situation. An association with tubulointerstitial nephritis and nephrotic syndrome has also been occasionally reported for penicillin/ amoxicillin induced nephropathies [86]. Several reports have analyzed T-cells in penicillin-induced allergy. CD4 T-cells specific for penicillin may be derived from the patients and produce mainly lL-5, some of them being perforin positive with a cytolytic potential [87]. 2) P-lactam specific clones may be obtained only from patients with adverse reactions the clones were Th2 whatever the type of clinical manifestations and... 

Effect of human milk, and the role of milk constituents (e.g. n3/n6 fatty acids, a-linolenic acid and cytokines) in the development of sensitisation and clinical manifestations of allergy. 

Role of indoor air and ambient air pollutants in the development of sensitisation and clinical manifestations of allergy. 

Allergies of type IV thus appear after cellular mediation and without any production of antibodies. For this reason, desensitization is not possible (Dooms-Gossens et al. 1980 Dupuis and Benezra 1982 Hildebrand et al. 1989a, 1989b). The immunological feature is called (hyper-)sensitization, and one speaks of an allergy when clinical manifestations appear. 

T Fuchs, HJ Gonzl. Clinical manifestation and diagnosis of natural latex allergy. Allergologie 9 350-357, 1995. 

Clinical Manifestations. The initial manifestations of bronchial asthma can occur at any age. However, the vast majority of extrinsic asthmatics first note symptoms as children or young adults, and those who appear in later decades often have had some earlier manifestation of atopy or allergy. On the other hand, intrinsic asthma generally occurs after the age of 30. Other differences between these two types of asthmatics are noted in Table II. Any individual patient may demonstrate some overlap of these features. For example, the extrinsic asthmatic may be continuously exposed to the specific antigenCs) and, therefore, have symptoms chronically. 

The most frequent manifestations of drug allergy involve the skin. Urticaria, angioedema, exanthematous skin rashes, allergic eczematous contact dermatitis, photodermatitis, fixed drug eruptions, erythema multiforme, and the Stevens-Johnson and Lyell syndromes are the best characterized clinical manifestations. Their clinical aspects, evolution, and pathophysiological mechanisms are described in detail in the following chapter. 

The case history and other clinical manifestations in some of the patients with reactions to suxamethonium leaves little doubt that allergy can develop in response to the administration of this agent, which is an acetylcholine analogue. The acute reaction in these cases was therefore very likely to have been due to typical IgE-mediated anaphylaxis. Cases of similar reactions have been reported by other authors, e.g. Jerums et al. (1967), Royston and Wilkes (1978). This aspect, the immune reaction to succinylcholine is considered so fundamentally important as to warrant full consideration. The preliminary studies of Hadji and Benveniste (1980) suggest that sensitization of guinea-pigs to suxamethonium can be induced by repeated injection. 

Wilson CWM (1976 b) The relationship of the leucocyte ascorbic acid direct antigen challenge test (LAADACT) to the clinical manifestations of allergic sensitivity. Clin Allergy 6 414-415... 

Eosinophilic gastroenteritis is an uncommon condition of unknown aetiology, although it is generally believed to be due to intestinal allergy. Its clinical manifestations can be very heterogeneous, and the disease may mimic peptic ulcer, subacute (or chronic) intestinal obstruction, gastroenteritis, irritable bowel syndrome, or inflammatory bowel disease. 

In acute toxicity, the main clinical manifestations are pulmonary edema, allergy, nausea, vomiting, and hemorrhage. 

In chronic toxicity, the clinical manifestations are pulmonary syndrome, skin syndrome, allergy, gastrointestinal irritations, nausea, cardiomyopathy, hematological disorders, and thyroid lesion. 

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