Biosynthesis monoterpene indole alkaloids

Salim V, De Luca V. Towards complete elucidation of monoterpene indole alkaloid biosynthesis pathway Catharanthus roseus as a pioneer system. In Advances in Botanical Research - New Light on Alkaloid Biosynthesis and Future Prospect. 2013. p. 1-37. 

O Connor SE, Maresh JJ (2006) Chemistry and biology of monoterpene indole alkaloid biosynthesis. Nat Prod Rep 23 532-547... 

This review of the biosynthesis of the bisindole alkaloids of C. roseus is organized along a developing biosynthetic pathway, as far as possible, and relies on the notion that the most sophisticated studies are those utilizing the purified enzyme systems. Biosynthetic studies on the other monoterpene indole alkaloids are not reviewed here. 

Keywords alkaloid biosynthesis alkaloid genes nicotine tropane alkaloids pyrrolizidine alkaloids benzylisoquinoline alkaloids monoterpene indole alkaloids ergot alkaloids acridone alkaloids purine alkaloids taxol betalains... 

Buriat, V., Oudin, A., Courtois, M., Rideau, M. and St. Pierre, B. (2004) Co-expression of three MEP pathway genes and geraniol-lO-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular location of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. Plant., 38,131 1. 

Development of transcrip-tomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species. PLoS One, 7, e52506. 

Biosynthesis A. is formed from tryptamine and the monoterpene secologanin (see secoiridoids) via stric-tosidine, catalysed by ca. 10 known enzymes (see also figure under monoterpenoid indole alkaloids). 

Asymmelric kydroboradon. A key step in an asymmetric synthesis of loganin (I), a key intermediate in the biosynthesis of indole and monoterpene alkaloids, involved... 

This is a very large group of alkaloids whose basic structure contains a pyrrole ring fused to a benzene ring. Biosynthesis of pure indoles involves the amino acid tryptophan as precursor, while that of a major subgroup of the indoles, including the Catharanthus and Rauwolfia alkaloids, involves a second precursor— the monoterpene iridoid loganin. 

---