Alkaloids diterpenoid

Sultankhodzhaev et al. (2005) reported tyrosinase inhibition studies on 15 diterpenoid alkaloids with the lycoctonine skeleton, and their semisynthetic... 

Sultankhodzhaev MN et al. (2005) Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives structure-activity relationships. Nat Prod Res 19(5) 517-522... 

Diterpenoid alkaloids Aconitum leucostomum SiOj CHCI3 - MeOH - MCjCO DragendorlTs reagent IR, NMR, EI-MS 12... 

Zhao XY, Wang Y, Li Y, et al. Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABAa receptor antagonist in rat brain. Neurosci Lett 2003 337 33-36. 

The genera of Aconitum (commonly known as Monkshood) and Delphinium, and to a lesser extent Rumex, Consolida, and Spiraea, have long been recognized as a rich source of alkaloid natural products [1], The diterpenoid alkaloids are generally classified into two major groups the Ci9-diterpenoid alkaloids (sometimes referred to as the Cig-norditerpenoid alkaloids) and the C2o-diterpenoid alkaloids. Within the C2o-diterpenoid alkaloids, at least 11 separate classes have been isolated, including the hetisine alkaloids (Chart 1.1). 

Wada K, Mori T, Kawahara N. 2000. Stereochemistry of nor-diterpenoid alkaloids by liquid chromatography/atmo-spheric pressure chemical ionization mass spectrometry. J Mass Spectrom 35 432. 

Distribution of alkaloids in traditional Chinese medicinal plants, 32, 241 (1988) Diterpenoid alkaloids Aconitum, 7, 473 (1960), 12, 2 (1970)... 

Peng, C. S., Chen, D. L., Chen Q. H. and Wang, F. P. 2005. New diterpenoid alkaloids from roots of Aconitum sinomontanum. Chinese Journal of Organic Chemistry, 25 1235-1239. 

Diterpenoid Alkaloids.—The structure and synthesis of the diterpenoid alkaloids have been reviewed. The subject is also covered in detail in the Specialist Periodical Report on the Alkaloids. A number of new alkaloids with the ent-kaurene skeleton have been isolated from Anopterus glandulosus and A. macleayanus. The structure of the major alkaloid anopterine (104) was assigned ... 

Carbon-13 and Proton NMR Shift Assignments and Physical Constants of Diterpenoid Alkaloids... 

C-Chemical Shifts of Various Functional Groups of Cjo-Diterpenoid Alkaloids S... 

Index of Naturally Occurring Diterpenoid Alkaloids and their Derivatives 13... 

Diterpenoid alkaloids have been isolated from the genera of the families Ranunculaceae (Aconitum, Consolida, Delphinium, Thalictrum), Garryaceae (Garraya), Rosaceae (Spiraea), and Compositae (Inula). These alkaloids can be divided into two broad categories norditerpenoid alkaloids (based on a C -skeleton) and the diterpenoid alkaloids (based on a Cft-skeleton).1 The chemistry of the diterpenoid alkaloids has been reviewed in earlier literature. ... 

Structure determination of the diterpenoid alkaloids (C20) has been a challenging task because of the diverse skeleta of these alkaloids. During the period ( 1962-1972), many of the structures were determined by X-ray crystal structure determination. The development of high resolution NMR and Mass spectral instruments has facilitated the structure elucidation and determination of the stereochemistry of the diterpenoid alkaloids. The structures of more than 240 naturally occurring diterpenoid alkaloids have been determined in the past twenty five years making use of, 3C NMR studies. 

The naturally occurring diterpenoid alkaloid miyaconitinone (Al-type) contains a diketone at the C(6), C(7) positions and caidionidine (Al-type) possesses an anhydride group in the B-ring between C(6), C(7). In albovionitine (Al-type), the C(18) methyl... 

The present catalogue provides proton and/or carbon-13 NMR chemical shift assignments and physical constants for many of the naturally occurring diterpenoid alkaloids and their derivatives. The literature search is not intended to be exhaustive. It is hoped that the 13C NMR data bank will serve as a useful guide for determining the structures of newly isolated alkaloids. 

BS Joshi and SW Pelletier, Recent Developments in the Chemistry of Norditerpenoid and Diterpenoid Alkaloids in Alkaloids Chemical and Biological Perspectives , (SW Pelletier, ed.), Vol 13, Chapter 4, pp. 292-2362, Pergamon Press, Amsterdam, 1999. 

Diterpenoid Alkaloid Natural Occurrence (N) Derivative (D) Structure Type X-Ray H c... 

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