Alginate nanoparticles

I. Aynie, C. Vauthier, E. Fattal, and M. Foulquier, Alginate nanoparticles as a noval carrier for antisense oligonucleotides, in Future Strategies for Drug Delivery with Particulate Systems, Stuttgart, 1997, pp. 11-16. 

Microspheres and nanoparticles often consist of biocompatible polymers and belong either to the soluble or the particle type carriers. Besides the aforementioned HPMA polymeric backbone, carriers have also been prepared using dextrans, ficoll, sepharose or poly-L-lysine as the main carrier body. More recently alginate nanoparticles have been described for the targeting of antisense oligonucleotides [28]. As with other polymeric carrier systems, the backbone can be modified with e.g. sugar molecules or antibody fragments to introduce cellular specificity. 

Aynie IC, Vauthier C, Fattal E, Foulquier M, Couvreur P (1998) Alginate nanoparticles as a novel carrier for antisense oligonucleotide. In Diederichs JE, Muler R (eds), Future Strategies of Drug Delivery with Particulate Systems. Stuttgart Medipharm Scientific Publisher, pp 5-10... 

Zahoor, A., Sharma, S., and Khuller, G. K. (2005), Inhalable alginate nanoparticles as antitubercular drug carriers against experimental tuberculosis, Int. I. Antimicrob. Agents, 26(4), 298-303. 

Aynie I, Vauthier C, Chacun H, et al. (1999). Spongelike alginate nanoparticles as a new potential system for the delivery of antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 9 301-312. 

Reis, C. R, Ribeiro, A. J., Neufeld, R. J., and Veiga, E. Insulin-loaded alginate nanoparticles obtained by emulsification/intemal gelation. XII International workshop on bioencapsulation 24-26 September 2004 Vitoria, Spain Servicio editorial Universidad del Par s Vasco, 2004, p. 251. 

Azizi, E., Namazi, A., Haririan, 1., Fouladdel, S., Khoshayand, M. R., Shotorbani, Parisa, Y., Nomani, A., and Gazori,T. (2010). Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector, Int J. Nanomed., 5,455-461. 

Motwani, S.K., Chojna, S., Talegaonkar, S., Kohli, K., Ahmad, F.J., Khar, R.K. Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery Formulation, optimization and in vitro characterization. Eur. J. Pharm. Biopharm. 68, 513-525 (2008)... 

Chitosan/alginate nanoparticles of about 150-340 nm diameter were used to encapsulate a cationic a-cyclodextrin (a-CD) which complexed insulin. These nanoparticles protected, to some extent, insulin from degradation by pepsin while being able to release insulin. ... 

MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazoIium) assay. Saraei et al. [40] investigated alginate nanoparticles containing a model protein, bovine serum albumin (BSA), by the ionotropic gelation technique. The average particle size of the BSA-loaded alginate nanoparticles was 50nm, the zeta potential was -24 mV, and the polydispersity index was 0.36. 

Oral delivery of insulin is important because endogenous insulin enables prolonged control of the glycenuc effect in diabetic patients. Mukhopadhyay et al. [66] formulated chitosan/alginate nanoparticles by simple ionotropic gelation techniques for insulin delivery. The particle size range of the nanoparticle was 100-200nm, and the encapsulation efficiency of insulin was approximately 85%. The in vitro release of insulin was 26.7% for 2h in acidic medium (pH 1.2) and 79-84% for approximately 24h in intestinal medium (pH 6.8 and 7.4). The in vivo evaluation showed an increase... 

F. Saraei, N. Mohamadpour Dounighi, H. Zohagharian, S. Moradi Bidhendi, P. Khaki, F. Inanlou, Design and evaluate alginate nanoparticles as a protein dehvery system. Archives of Razi Institute 68 (2013) 139-146. 

S. Jain, T. Tran, M. Amiji, Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis. Biomaterials 61 (2015) 162-177. 

An alginate-based nanoparticulate delivery system was developed for frontline antituberculosis dmgs (rifampicin, isoniazid, pyrazinamide and ethambutol). Alginate nanoparticles were prepared by controlled cation-induced gelification and administered orally to mice. The drug levels were analysed by high performance liquid chromatography (HPLC) in plasma and tissues. The therapeutic efficacy was... 

Polyvinyl alcohol/sodium alginate Nanoparticles Antibacterial activity [28]... 

Khampieng T, Aramwit P, Supaphol P. Silk sericin loaded alginate nanoparticles preparation and anti-inflammatory efficacy. Int J Biol Macromol. 2015 80 636-43. 

Li P, Dai YN, Zhang JP, Wang AQ, Wei Q. Chitosan-alginate nanoparticles as a novel drug debvery system for nifedipine. Int J Biomed Sci 2008 4 221-228. 

Alginate nanoparticles can be used as oral insulin carrier or glucose binder in the treatment of diabetes as a function of its chemical composition. High molecular weight M-rich alginate nanoparticles are a suitable vehicle for future development into oral insulin carrier (Kadir et al., 2013). 

Ahmad Z, Pandey R, Sharma S, Khuller GK. Alginate nanoparticles as antituberculosis drug carriers formulation development, pharmacokinetics and therapeutic potential. Indian J Chest Dis Allied Sci... 

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