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Albumin, human, fraction

Normal serum was pooled from normal donors, stored for several hours at 37 °C, and frozen in glass tubes. Rabbit antisera to the following human proteins From Hyland, antisera to albumin (list 071-107), fibrinogen (list 071-108), human fraction III-I (list 071-103), -lipoproteins (list 071-113), human serum (list 071-121), Fab (071-258), Fc (071-259). From Mann Research Labs., antisera to 7s gamma-globulins (cat. 231) and total gamma-globulins (cat. 8090). From Hoechst, Woodbury, N. Y. antiserum to pre-albumin (code 8506). [Pg.263]

Albumin human (USP 28) Albumin human is a sterile non-pyrogenic preparation of serum albumin that is obtained by fractionating material (source blood, plasma, serum, or placentas) from healthy human donors. The source material is tested for the absence of hepatitis B surface antigen. It is made by a process that yields a product safe for intravenous... [Pg.17]

Human serum albumin (HSA) (fraction V) and Plasma (Catalog No. P-9523) were purchased from Sigma Chemical Company, Inc., poly(ethylene imine) (PEI) (MW 600 Da) from Polysciences, Inc., 1,4-butanediol diglycidyl ether (BUDGE) from Aldrich Chemical Company, Inc. and Cibacron Blue F3GA from Fluka. All other reagents were ACS grade. [Pg.298]

Inactivation and Removal of Viruses. In developing methods of plasma fractionation, the possibiHty of transmitting infection from human vimses present in the starting plasma pool has been recognized (4,5). Consequentiy, studies of product stabiHty encompass investigation of heat treatment of products in both solution (100) and dried (101) states to estabHsh vimcidal procedures that could be appHed to the final product. Salts of fatty acid anions, such as sodium caprylate [1984-06-17, and the acetyl derivative of the amino acid tryptophan, sodium acetyl-tryptophanate [87-32-17, are capable of stabilizing albumin solutions to 60°C for 10 hours (100) this procedure prevents the transmission of viral hepatitis (102,103). The degree of protein stabilization obtained (104) and the safety of the product in clinical practice have been confirmed (105,106). The procedure has also been shown to inactivate the human immunodeficiency vims (HIV) (107). [Pg.530]

Fig. 6. Share of U.S. market occupied by human albumin/plasma protein fraction, (—) Factor VIII concentrate, (-) intravenous immunoglobulin... Fig. 6. Share of U.S. market occupied by human albumin/plasma protein fraction, (—) Factor VIII concentrate, (-) intravenous immunoglobulin...
Table 9. Properties of Human Albumin and Plasma Protein Fraction ... Table 9. Properties of Human Albumin and Plasma Protein Fraction ...
Characteristic Human albumin Plasma protein fraction ... [Pg.535]

Albumin. Investigation iato the safety of bovine plasma for clinical use was undertaken ia the eady 1940s ia anticipation of wartime need (26). Using modem proteia chemistry methods, including electrophoresis and ultracentrifugation, it was shown that most of the human adverse reactions to blood substitutes were caused by the globulin fraction and that albumin was safe for parenteral use. Human albumin is now used extensively as a plasma expander ia many clinical settings. [Pg.161]

Plasma protein fractions include human plasma protein fraction 5% and normal serum albumin 5% (Albuminar-5, Buminate 5%) and 25% (Albuminar-25, Buminate 25%). Plasma protein fraction 5% is an IV solution containing 5% human plasma proteins. Serum albumin is obtained from donated whole blood and is a protein found in plasma The albumin fraction of human blood acts to maintain plasma colloid osmotic pressure and as a carrier of intermediate metabolites in the transport and exchange of tissue products. It is critical in regulating the volume of circulating blood. When blood is lost from shock, such as in hemorrhage, there is a reduced plasma volume. When blood volume is reduced, albumin quickly restores the volume in most situations. [Pg.634]

MARIOTTI F, PUEYO M E, TOME D, BEROT S, BENAMOUZIG R, MAKE S (2001) The influence of the albumin fraction on the bioavailability and postprandial utilization of pea protein given selectively to humans. /Awir. 131 1706-13. [Pg.181]

Albumin is a protein derived from fractionating human plasma. Because albumin infusion is expensive and may be associated with adverse events, it should be used for acute... [Pg.406]

Distribution. Lead in blood partitions between plasma and red blood cells, with the larger fraction (90-99%) associated with red blood cells (Cake et al. 1996 DeSilva 1981 Everson and Patterson 1980 Manton and Cook 1984 Ong and Lee 1980a). Lead in plasma binds to albumin and y -globulins (Ong and Lee 1980a). The fraction that is not bound to protein exists largely as complexes with low molecular weight sulfhydryl compounds these may include cysteine, homocysteine, and cysteamine (Al-Modhefer et al. 1991). Approximately 75% was bound to protein when whole human blood was incubated with 50 ig/dL lead (as lead chloride) approximately 90% of the bound lead was associated with albumin (Ong and Lee 1980a). However, the fraction of lead in plasma bound to protein would be expected to vary with the plasma lead concentration. [Pg.256]

FIGURE 12.5 Human serum tryptic digest analysis. Fractionation in the first LC dimension was performed using a C18 column at pH 10. Fractions were analyzed using NanoEase 0.3 x 150 mm Atlantis d18 column. Approximately 66 lg (400 pmole of semm albumin peptides) was injected on column. Arrow points to a selected albumin peptide illustrating a local column mass overloading. Ten-5mm wide fractions were collected in 1st LC dimension. [Pg.283]

A report on the binding of the anesthetic propofol to human serum albumin and to plasma presents a dataset that challenges simple notions of equilibria [70]. The unbound fraction of propofol was found to increase sharply at low drug concentrations. The authors appear to have carefully eliminated possible artifacts. Explanations based on cooperative binding modes are discussed though no clear explanation emerges. [Pg.498]


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