Alanine aminotransferase, analysis

Liver dysfunction. In a 4-year study in 1221 liver dysfunction-free (serum aspartate aminotransferase [AST] and alanine aminotransferase [ALT] <39 lU/L and no medical care for or no past history of liver disease) males aged 35-56 years, was investigated for the association of coffee consumption with the development of increased serum AST and/or ALT activities. From the analysis using the Kaplan-Meier method, the estimated incidence of serum AST and/ or ALT > 40 lU/L, > 50 lU/L, and > 60 lU/ L decreased with an increase in coffee consumption. From the Cox proportional haz-... 

A total of 8388 observations (i.e., concentration values) from 906 patients was used for this analysis. The following covariates were investigated for a possible impact on the PK of cetuximab age, gender, race, BSA, creatinine clearance, bilirubin, alanine aminotransferase, aspartate aminotransferase, concomitant therapy, hepatic status and renal status. 

Dufour D R. Alanine aminotransferase variation in chronic hepatitis C infection An analysis of 357 cases. Chn Chem 2001 47 A26-A7. 

In clinical trials, patients were identified based on the molecular analysis using the same diagnostic kit from Abbott employed to detect ALK fusions. Crizotinib was administrated orally at the standard dose of 250 mg twice daily in a 28-day cycles. Based on a cohort of 50 advanced NSCLC patients with ROS 1 rearrangement, the ORR was 72%. The safety profile of crizotinib in these new patient populations was similar to that observed in patients harboring ALK-fusion mutations. For example, the most common treatment-related adverse effects (grade 3) were hypophosphatemia, neutropenia, and an elevated alanine aminotransferase level. There were no treatment-related grade 4 or 5 adverse events in the ROSl patients." ... 

In a recent study, DR mice exhibited lower inflammatory damage induced by LPS. Balb/c mice were subjected to 40% DR and challenged with 25 pg of LPS. The DR mice had attenuated increases in the proinflammatory cytokines consistent with the lower liver damage characterized by lower plasma alanine aminotranferase (ALT), aspartate aminotransferase (AST) and histopathological analysis. The DR mice also had higher circulating corticosterone, a mediator of antiinflammatory action in DR,... 

As with the other B vitamins that act as coenzymes biochemical assessment of vitamin Bg can, be made by direct chemical analysis of the vitamer or its metabolites, or by functional means. Measurements that have been used are PLP in plasma or red cells, its metabolite 4 PA in urine or plasma, the activity and activation coefficient of the red cell aminotransferases (aspartate and alanine), and the tryptophan load metabolite excretion test. As no single marker adequately reflects status, a combination of these markers olfers the best approach. 

ADP AFP ab as ALAT AP ASAT ATP BQ BSA CEH CK CME COD con A CV d D E E EC ECME EDTA EIA /e FAD FET FIA G GOD G6P-DH HBg HCG adenosine diphosphate a-fetoprotein antibody antigen alanine aminotranferase alkaline phosphatase aspartate aminotransferase adenosine triphosphate benzoquinone bovine serum albumin cholesterol ester hydrolase creatine kinase chemically modified electrode cholesterol oxidase concanavalin A coefficient of variation (relative standard deviation) layer thickness diffusion coefficient enzyme potential Enzyme Classification enzyme-chemically modified electrode ethylene diamine tetraacetic acid enzyme immunoassay enzyme loading factor flavin adenine dinucleotide field effect transistor flow injection analysis amplification factor glucose oxidase glucose-6-phosphate dehydrogenase hepatitis B surface antigen human chorionic gonadotropin... 

Acute hepatitis mimicking iron overload syndrome was reported in a 35-year-old man who had been taking fo-ti (dose and duration unspecified). Laboratory studies included alanine transferase 2714 U/1 (normal <50 U/1), aspartate aminotransferase 1170 U/1 (normal <50 U/1), AP 137 U/1 (normal <130 U/1), total bilirubin 4.6 mg/dl (normal <1.4 mg/dl), direct bilirubin 3.0 mg/dl (normal <0.4 mg/dl), and ferritin 13,862 ng/ml (normal 8 to 282 ng/ml) and a fasting transferrin saturation of 86% (normal 20% to 60%). Analysis of the herbal supplement identified extracts from fo-ti including the anthraquinones emodin and physcion. The patient recovered after cessation of the herbal products, and liver function tests 4 months after hospitalization were normal (Laird et al. 2008). 

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