Blood pool agent

Idee J-M, Tichkowsky I, Port M, Petta M, Le Lem G, Le Greneur S, Meyer D, Corot C (2002) lodiated Contrast Media from Non-Specific to Blood-Pool Agents. 222 151-171 Igau A, see Majoral J-P (2002) 220 53-77 Imamoto T, see Crepy KVL (2003) 229 1-40 Iwaoka M, Tomoda S (2000) Nucleophilic Selenium. 208 55-80... 

The noncovalent approach is based on the use of complexes containing suitable moieties which are able to recognize specific proteins, primarily human serum albumin (HSA). When the targeting protein is confined in the blood, the adduct between the serum albumin and the functionalized complex may function as a blood pool agent. Due to the reversible nature of binding between the protein and the paramagnetic chelate, these adducts maintain excretory pathways typical of small complexes which, from the pharmacological point of view, favors them over covalently bound macromolecules. 

Keywords. Blood Pool Agents, Monodisperse lodinated Macromolecules, Computed Tomography, Pharmacokinetics, Safety Profile... 

Fig. 1. Schematic compartmental pharmacokinetic representation of different classes of contrast agents a. nonspecific agent (NSA e.g. iobitridol) b. low-diffusion agent (LDA) c. rapid-clearance blood-pool agent (RCBPA e.g. P743) d. slow-clearance blood-pool agent (SCBPA, e.g. P840). From Id e et al. (2001) Invest Radiol 26 41,with permission ( Lippincott Williams Wilkins)...

The fifth chapter is dedicated to macromolecular iodinated contrast agents with low dispersity. They can be utilized as blood-pool agents. The synthesis, analysis and pharmacokinetics of this class of compounds is summarized and their diagnostic impact is evaluated. 

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