Serum gastrin

Acid rebound Antacids may cause dose-related rebound hyperacidity because they may increase gastric secretion or serum gastrin levels. 

Cimetidine, ranitidine, and famotidine have no effect on gastric emptying, and cimetidine and famotidine have no effect on lower esophageal sphincter pressure. Ranitidine, nizatidine, and famotidine have little or no effect on fasting or postprandial serum gastrin. 

Effect of Candidate Compounds with Antisecretory Potential on Serum Gastrin Levels... 

Serum gastrin levels are determined as pg/ml. Statistical differences (p < 0.05) are calculated using appropriate statistical methods. 

Katz et al. (1987) described a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. 

Katz LB, Schoof RA, Shriver DA (1987) Use of a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. J Pharmacol Meth 18 275-282 Larsson H, Carlsson E, Mattsson H et al. (1986) Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 90 391-399... 

The experiment described in the following section illustrates some of the broad properties of gastrin. The study shows that the levels of serum gastrin artd stomach acid secretion both increase after a meal in a human subject. In isolation, this information does not provide evidence that the rise in scrum gastrin generates the release of gastric acid. Additional evidence is needed to make a firm connection between hormonal levels and the behavior of the parietal cells. Therefore, the study also includes an experiment of an invasive nature, that is, infusion of gastrin. Infusion means a slow injection, perhaps over the course of an hour... 

In four children with nephropathic cystinosis receiving mercaptamine 14.35 mg/kg qds serum gastrin concentrations up to 90 minutes later rose as did gastric acid output (10). Two of the four subjects had visual and histological evidence of gastric inflammation. The clinical effect of this acid production is unknown. 

To test whether omeprazole accelerates healing of standardized gastroduodenal lesions in the presence of diclofenac, 12 healthy volunteers took consecutive 2-week courses of omeprazole 40 mg/day or placebo, with diclofenac given in the second week of each course, in a double-blind, crossover study (3). Omeprazole did not accelerate the healing of pre-existing mucosal lesions or prevent the development of small diclofenac-induced mucosal lesions. Omeprazole increased serum gastrin in all subjects. 

Ligumsky M, Lysy J, Siguencia G, Friedlander Y. Effect of long-term, continuous versus alternate-day omeprazole therapy on serum gastrin in patients treated for reflux esophagitis. J Chn Gastroenterol 2001 33(l) 32-5. 

Bieberdorf FA, Walsh JH, Fordtran IS. Effect of optimum therapeutic dose of poldine on acid secretion, gastric acidity, gastric emptying, and serum gastrin concentration after a protein meal. Gastroenterology 1975 68(l) 50-7. 

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