YIGSR laminin peptide

Mu Y et al (1999) Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells. Biochem Biophys Res Commim 255 75-79... 

J. Tanaka, Effects of a laminin peptide (YIGSR) immobilized on crab-tendon chitosan tubes on nerve regeneration, J. Biomed. Mater. Res. B Appl. Biomater. 73 (2005) 375-382. 

Further improvements have been achieved using thiolated and non-thiolated hydro)g apatite-coated crab-tendon chitosan (t-chitosan/HAP-SH and t-chitosan/HAP, respectively) tubes, with and without a conjugated laminin peptide sequence (YIGSR). Laminin-1 is considered to be one of the most important cell adhesion molecules, and a pentapeptide sequence (YIGSR) located at its B1 domain is believed to enhance Schwann-cell migration and attachment, as well as neural outgrowth. 

Massia, S.P, Rao, S.S., and Hubbell, J.A., Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kDa laminin receptor with alpha-actinin and vinculin./. Biol. Chem., 1993,268 8053-8059. 

Zalipsky S, et al. Peptide attachment to extremities of liposomal surface grafted PEG chains preparation of the long-circulating form of laminin pentapeptide, YIGSR. Bioconjugate Chem 1995 6 705. 

Zhao M, Kleinman HK, Mokotoff M. Synthesis and activity of partial retro-inverso analogs of the antimetastatic laminin-derived peptide, YIGSR-NH2. J Peptide Res... 

Neurite extension can be controlled using immobilized peptides. RGD peptides linked to PLXA-PEG-biotin surfaces via a stieptavidin linker were shown to spatially control the adhesion and the direction of neurite extension from PC12 cells (Patel et al., 1998). Neurite extension from PC12 cells and NG108-15 neuroblastoma cells was also spatially controUed using laminin-derived peptides YIGSR and KVAV bound to fluorinated ethylene propylene films (Ranieri et al., 1994). These smdies demonstrate the potential impact of peptides on die regeneration of nerve tissues. 

Laminin IKVAV peptide Laminin F9 peptide Laminin YIGSR peptide... 

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