Yamazaki studies

In 1948, Reppe reported the first example of the transition metal-catalyzed [2+2+2] cycloaddition of alkynes by using a nickel complex [2]. Vollhardt extensively studied utilization of the cobalt-mediated [2+2+2] cycloaddition in organic synthesis [3a, b], and Yamazaki studied general reactivity of... 

Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., Guengerich, F. P., Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals studies with liver microsomes of 30 Japanese and 30 Caucasians, J. Pharmacol. Exp. Ther. 1994, 270, 414— 423. 

Turnbull JJ, Nakajima J, Welford RW, Yamazaki M, Saito K and Schofield CJ. 2004. Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis anthocyanidin synthase, flavonol synthase, and flavanone 33-hydroxylase. J Biol Chem 279 1206-1216. 

A major effort in contemporary olfactory research has focused upon determining the genetic basis of odours of individuality in mice with both major urinary proteins (MUPs) and the major histocompatibility complex (MHC) believed to provide a contribution to discriminable individual differences (Singer, Beauchamp and Yamazaki 1997 Hurst and Beynon 2004). Many of these studies utilized instrumental conditioning tasks in which the animals were rewarded for learning to discriminate between odours. While these experiments demonstrate what an animal... 

Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals studies... 

M. Masuhara, S. Tazuke, N. Tamai, and I. Yamazaki, Time-resolved total internal reflection fluorescence spectroscopy for surface photophysics studies, J. Phys. Chem. 90, 5830-5835 (1986). 

Kodaira K, Fujishiro K, Wada T, Male K, Satoi T, Tsukiyama E, Fukumoto T, Uchida T, Yamazaki S, Okamura T (1993) A study on cerebral nicotine receptor distribution, blood flow, oxygen consumption, and other metabolic activities-a study on the effects of smoking on carotid and cerebral artery blood flow. Yakubutsu Seishin Kodo 13 157-165... 

The hexafluoroantimonate salt of the terthiophene cation-radical in which terminal thiophene was completely surrounded by bicycle[2.2.2] octane units was studied by x-ray crystallography (Nishinaga et al. 2004). In the crystal lattice, the authors did not find only one isomer. They wrote about the dominant form, which was an x-trans-trans conformer. The central thiophene ring remains free, and only the terminal rings are fused with the bicycle[2.2.2] octane units—this cation-radical acquires a bent conformation. As B3LYP calculations show, the all-anti conformer is more stable than the all-syn counterpart by 5.35 kJ moY (Yamazaki et al. 2006). 

Hirai, M. Y., Suzuki, H., Yamazaki, M. and Saito, K. 2000. Biochemical andpatrial molecular characterization of bitter and sweet form of Lupinus angustifolius, an experimental model for study of molecular regulation of quinolizidine alkaloids biosynthesis. Chemistry and Pharmacy. Bulletin, 48 1458-1461. 

Hayashi, S., Kii, Y, Tabo, M., Fukuda, H., Itoh, T., Shimosato, T., Amano, H., Saito, M., Morimoto, H., Yamada, K., Kanda, A., Ishitsuka, T., Yamazaki, T., Kiuchi, Y, Taniguchi, S., Mori, T., Shimizu, S., Tsurubuchi, Y, Yasuda, S., Kitani, S., Shimada, C., Kobayashi, K., Komeno, M., Kasai, C., Hombo, T. and Yamamoto, K. (2005) QT PRODACT A multi-site study of in vitro action potential assays on 21 compounds in isolated guinea-pig papillary muscles. Journal of Pharmacological Sciences, 99, 423-437. 

A somewhat different view is supported by a number of other studies. Behavioural rhythmicity persists in SCN-lesioned rodents under the influence of either periodically available food (Davidson Stephan 1999, Stephan et al 1979) or continuous treatment with methamphetamine (Honma et al 1992). Rhythmicity of at least some circadian genes persists in isolated peripheral tissues for periods of time ranging from several days to two or three weeks (Yamazaki et al 2000, our unpublished results). Removal of the retina (which is known to contain its own circadian oscillator Tosini Menaker 1996) changes the distribution of free-running periods of locomotor activity and the duration of active time (a) (Yamazaki et al 2002a). To pursue our metaphor, these results suggest that circadian signals may be relayed to the periphery by a baton rather than a whip the SCN may indeed be the conductor of an orchestra composed of dozens, if not thousands of potentially independent oscillators. 

This was followed by Taback s (94) study of the effect of copper chromite catalyst additives. In general, the results of these investigations fitted the Summerfield relation remarkably well over the range 1—100 atm. (Figures 3 and 6). Moreover, the effects of propellant composition and oxidizer particle size on the constants a and b, respectively, were consistent with qualitative predictions from the theory. Similar results have since been obtained by Yamazaki (101), Marxman (18), and the group at ONERA (8, 52, 64) in France (Figure 7). An alternative to the above equation has been proposed by Penner et al. (68)—i.e., (1/r)2 = (a/p)2 + (b/pm)2. A systematic survey (91) of all available data shows that when... 

Shoko Yamazaki was born in Osaka, Japan. She studied chemistry at Osaka University and received her Ph.D. in 1986 under the supervision of Prof. Ichiro Murata. From 1985, she was an assistant lecturer at Nara University of Education. She joined the group of Professor Barry M. Trost as a visiting researcher at Stanford University (USA) in 1987-88. She became an assistant professor at Nara University of Education in 1989 and since 2003, a full professor of Nara University of Education. Her current main research interests are the development of new organic synthetic reactions. 

Satoh Y, Yamazaki M (1989) Studies on the Monoamine Oxidase (MAO) Inhibitory Potency of TL-1, Isolated from a Fungus Talaromyces luteus. Chem Pharm Bull 37 206... 

Tanizaki, Y., Maeno, T., Nakamura, M. and Yamazaki, M. (1996) Use of an ultrafiltration and gamma-ray irradiation technique for studying the speciation of trace elements in river waters./. Environ. Sci. Health, A31, 913-940. 

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