White Blood Cell Pathology

Reactive Proliferations of White Blood Cells 1. Leukocytosis 

ALL is associated with infiltration of the CNS and testes (Sanctuary sites). Prophylactic radiation and/or chemotherapy to the head is recommended because malignant cells in brain are protected from chemotherapy by the blood-brain barrier. 

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) 

Peripheral T-Cell and Natural Killer Cell Neoplasms 

V RS variant Lacunar cells (dear space surrounding cell) c. Clinical characteristics 

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Clinical pathology (limited to evaluating the morphology of white blood cells, and usually this is actually deferred until there are indications that such data is needed) ... 

Immunocytochemistry and in situ hybridization techniques were used to detect HIV-1 infected cells in the testis (P5), excurrent ducts, and prostate. Distinct pathologic changes were observed in the majority of testis of AIDS patients that included azoospermia, hyalinization of the boundary wall of seminiferous tubules, and lymphocytic infiltration of the interstitium. In the testis, many white blood cells were shown to the CD4 + HIV-1 positive cells of lymphocy-tic/monocytic morphology, found in the seminiferous tubules and interstitium of the testis, epididymal epithelium, and connective tissue of the epididymis and prostate. There was no evidence of active HIV-1 infection in germ cells or Sertoli cells of the seminiferous tubules or other epithelial cells lining the excurrent ducts or prostatic glands. 

Thus, there are already available expert systems for differential diagnostics of many pathological conditions, such as diseases of red and white blood cells, disorders of blood clotting, toxic forms of hepatitis, and skin and mucous membrane lesions. 

Pearson et al (41) 1976 (sheep) Yes, in lymph node at < 1.0 hour pi (plaque assay) detected to 36 hrs pi clearance assoc, with t antiviral Ab Lymph node/no pathology noted Increased "white blood cells" particularly an increase in "large lymphocytes" noted post RRV infection in lymph node lavage... 

Possible physiological inhibitors of plasma lipoprotein lipase have been reported in plasma (Hollett and Meng, 1957), platelets (Hollett and Nestel, 1960), and white blood cells (Fekete et al., 1958). Their exact functional role remains to be established. Inhibition of plasma lipoprotein lipase activity has also been reported in pathological conditions, such as experimental pancreatitis (Kessler et al., 1962), clinical pancreatitis (Kessler et al., 1963), and idiopathic hyperlipemia (Klein and Lever, 1957). Several agents have been found to inhibit plasma lipoprotein lipase activity protamine and toluidine blue (Brown, 1952 Bragdon and Havel, 1954), Triton WR-1339 (Schotz et al., 1957), Triton A-20 and Tween 80 (Kellner et al., 1951), pituitary extracts (Rudman and Seid-... 

Proescher F, Almquest BR. 1914. Contribution on the biological and pathological action of soluble radium salts II Resume of the effect of soluble radium salts on the circulating blood cells of white mice and white rats. Radium 3 85-95. 

Three of the six goats in the high-dose test died before the exposure ended, so useful data were not obtained. All exposures, however, lowered the white-cell count and the hematocrit. No change in blood-gas contents was seen. No significant changes in biochemical or pathologic factors were found.1 ... 

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