Waveguide Raman spectroscopy

Kanger JS, Otto C, Slotboom M, Greve J (1996) Waveguide Raman spectroscopy of thin polymer layers and monolayers of biomolecules using high refractive index waveguides. J Phys Chem 100 3288-3292... 

Ferrari M., Gonella F., Montagna M., Tosello C. Detection and size determination of Ag nanoclustCTs in ion-exchanged soda-lime glasses by waveguided Raman spectroscopy. J. Appl. Hiys. 1996 79 2055-2059... 

Urlacher C., Mugnier J. Waveguide Raman spectroscopy used for structural investigations of Zr02 sol-gel waveguiding layers. J. Raman Spectr. 1996 27 785-792... 

Unfortunately, space constraints have prevented detailed discussions of an array of techniques that further enhance the utility of vibrational spectroscopy in polymer studies. These include surface enhanced Raman spectroscopy (SERS) and waveguide Raman spectroscopy for the study of surfaces, and for quality-control and process studies. The latter technique, particularly in conjunction with multivariate analysis software routines, is rapidly becoming important in monitoring and controlling modern production facilities. However, discussion of these and other areas can be found in many of the references cited in this chapter. 

A. F. (1988) Application of waveguide Raman spectroscopy to high-index dielectric films. Appl. Spectrosc., 42,... 

URL 96] URLACHER C., MUGNIER J., Waveguide Raman Spectroscopy used for struetural investigation of Zr02 sol-gel waveguiding layers , J. of Raman Spectroscopy, 27, p. 785, 19%. 

In summary, the optical and structural properties of PE and APE planar waveguides in LiNbOs and LiTaOs were studied. Raman spectroscopy was used to monitor the formation of various phases. 

In the decade since these first reports, various advances in blood serum Raman spectroscopy have been reported. As mentioned above, Qu developed a system with a waveguiding sample-filled capillary tube and two linear arrays of abutting fibers, with 100 mW sample illumination at 745 nm. On synthetic mixtures that simulated human serum, they obtained prediction errors for glucose and urea of 0.5 and 0.4mM, respectively [4]. 

Several optical methods have been used for DNA sensing, such as luminescence, fluorescence Raman or optical waveguide structure spectroscopy, and surface plasmon resonance (SPR). Various immobilization strategies to attach ssDNA to surfaces with the aim of attaining maximum selectivity and sensitivity have been described. 

Abstract Optical detection continues to dominate detection methods in microfluidics due to its noninvasive nature, easy coupling, rapid response, and high sensitivity. In this review, we summarize two aspects of recent developments in optical detection methods on microfluidic chips. The first aspect is free-space (off-chip) detection on the microchip, in which the conventional absorption, fluorescence, chemiluminescence, surface plasmon resonance, and surface enhanced Raman spectroscopies are involved. The second aspect is the optofluidic (inside-chip) detection. Various miniaturized optical components integrated on the microfluidic chip, such as waveguide, microlens, laser, and detectors are outlined. 

Schlotter, N. E., and Rabolt, J. F. Raman Spectroscopy in Polymeric Thin Film Optical Waveguides. 1. Polarized Measurements and Orientational Effects in Two-Dimensional Films. J. Phys. Chem. 88 2062-2067 (1984)... 

Raman spectroscopy in conjunction with waveguide technology is the accepted method used in... 

Ferrari M., Montagna M., Ronchin S., Rossi F., Righini G.C. Waveguide luminescence and Raman spectroscopy characterization of an inhomogeneous film at different depths. Appl. Phys. Lett. 1999 75 1529-1531... 

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