Vivo Evaluation

Andrews, J. T. Hembree, J. H. (1976). In vivo evaluation of the marginal leakage of four inlay cements. Journal of Prosthetic Dentistry, 35, 532-7. 

This preservative is comparatively new to ophthalmic preparations and is a polymeric quaternary ammonium germicide. Its advantage over other quaternary ammonium seems to be its inability to penetrate ocular tissues, especially the cornea. It has been used at concentrations of 0.001-0.01% in contact lens solutions as well as dry eye products. At clinically effective levels of preservative, POLYQUAD is approximately 10 times less toxic than benzalkonium chloride [87,137], Various in vitro tests and in vivo evaluations substantiate the safety of this compound [137,141,142], This preservative has been extremely useful for soft contact lens solutions because it has the least propensity to adsorb onto or absorb into these lenses, and it has a practically nonexistent potential for sensitization. Its ad-sorption/absorption with high water and high ionic lenses can be resolved by carefully balancing formulation components [143],... 

JH Lin, Y Sugiyama, S Awazu, M Hanano. In vitro and in vivo evaluation of the tissue-to-blood partition coefficients for physiological pharmacokinetic models. J Pharmacokin Biopharm 10 637-647, 1982. 

SA Varia, VJ Stella. Phenytoin prodrugs V In vivo evaluation of some water-soluble phenytoin prodrugs in dogs. J Pharm Sci 73(8) 1080-1087, 1984. 

Bakare AA, Mosuro AA, Osibanjo O (2005) An in vivo evaluation of induction of abnormal sperm morphology in mice by landfill leachates. Mutat Res 582 28-34... 

In vivo evaluation of the semi-simultaneous method for bioavailability estimation using controlled intravenous infusion as an... 

J. H., In vitro and in vivo evaluation of intestinal barriers for the zwitter-ions L-767,679 and its carboxyl ester prodrug L-775,318, Drug Metab. Disp. 1998, 26, 520-527. 

Program Capabilities In addition to the in vitro and in vivo evaluations for potential efficacy performed by the ATDP, the MDP includes the following capabilities to support the full range of drug development ... 

A peptide linker-chelate analog, glycyl-tyrosyl-lysine-N-e-DTPA (GYK-DTPA), was incorporated onto B72.3 antibody and labeled with 11 In and 90y.81,82 In vitro and in vivo evaluations in dogs were conducted. Results indicated that the 11 in chelate was stable in vivo however, the 90Y version showed a biphasic decay pattern. The covalent bond between the peptide and DTPA precluded use of one of the coordinating arms that is necessary to coordinate 90Y in a stable fashion. 

Hansmann D.R., Gehrich G.L., Practical perspectives on the in-vitro and in-vivo evaluation of a fiber optic blood gas sensor, Proc. SPIE 906 4 (1988). 

M.H. Schoenfisch, K.A. Mowery, M.V. Rader, N. Baliga, J.A. Wahr, and M.E. Meyerhoff, Improving the thromboresistivity of chemical sensors via nitric oxide release fabrication and in vivo evaluation of NO-releasing oxygen-sensing catheters. Anal. Chem. 72, 1119—1126 (2000). 

Venturini AP, Marchi E In vitro and in vivo evaluation of 17105, a new topical intestinal rifamycin. Chemioterapia (Florence) 1986,5 257-262. 

They avoid the complications (and potential confounding or masking findings) of animal and tissue/organ in vivo evaluation. 

Skalsky JL, Wrenn JM, Borzelleca JF. 1980. In vitro and in vivo evaluation of the movement of Kepone in the rat submaxillary gland. J Environ Pathol Toxicol 3(5-6) 529-536. 

United States Pharmacopoeia 27 (USP 27) National Formulary 22 (NF 22). United States Pharmacopeial Convention, Rockville, MD 2003 < 1088 > In vitro and In vivo Evaluation of Dosage forms 2334-2339. 

United States Pharmacopoeia, USP 26, National Formulary 21. General Chapter 1088 In Vitro and In vivo Evaluation of Dosage Forms United States Pharmacopeial Convention Rockville, MD, 2002 2334-2339. 

Usenko CY, Flarper SL, Tanguay RL (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon 45 1891-1898. 

Bolskar RD, Benedetto AF, Husebo LO, Price RE, Jackson EF, Wallace S, Wilson LJ, Alford JM (2003) First soluble M C60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd C60[C(COOH)J10 as a MRI contrast agent. J. Am. Chem. Soc. 125 5471-5478. 

Pristine CNTs are hydrophobic and cause a lack of solubility in biological aqueous fluids such as blood. The poor solubility of CNTs in blood stream poses a major challenge to in vivo studies making behavior of CNTs difficult to predict and control (Kam et al., 2005 Zheng et al., 2003a, b). Therefore, modification of CNT surface to introduce hydrophilic, functional groups has been utilized in pharmaceutical applications (Lacerda et al., 2006). However, insufficient in vivo evaluation of both pristine and surface-modified CNTs has been performed to answer essential questions on CNT toxicology. Additional in vivo studies also required to devise the best method of administration, means of uptake, metabolism, and elimination of CNTs. The in vivo studies on CNTs performed to date are presented in Table 12.2. 

S. T. K. Narishetty and R. Panchagnula. Transdermal delivery system for zidovudine In vitro, ex vivo and in vivo evaluation. Biopharm. Drug Dispos. 25 9-20 (2004). 

Okamoto H, Aoki M, Danjo K (2000) A novel apparatus for rat in vivo evaluation of dry powder formulations for pulmonary administration. J Pharm Sci 89 1028-1035. 

Sethia S, and Squillante E (2004) In vitro-in vivo evaluation of supercritical processed solid dispersions Permeability and viability assessment in Caco-2 cells. J. Pharm. Sci. 93 2985-2993. 

A. H. Krauland, V. M. Leitner, V. Grabovac, and A. Bernkop-Schnurch. In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. J Pharm Sci 95 2463-2472 (2006). 

C. Tas, C. K. Ozkan, A. Savaser, Y. Ozkan, U. Tasdemir, and H. Altunav. Nasal absorption of metoclopramide from different Carbopol 981 based formulations In vitro, ex vivo and in vivo evaluation. Eur J Pharm Biopharm 64 246-254... 

Bando H, Sahashi M, Yamashita F, Takakura Y, Hashida M (1997) In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model. Pharm Res 14 56-62. 

F. P. Bonina, L. Montenegro, P. de Caprariis, F. Palagiano, G. Trapani, G. Liso, In vitro and in vivo Evaluation of Polyoxyethylene Indomethacin Esters as Dermal Prodrugs , J. Controlled Release 1995, 34, 223-232. 

S. A. Varia, S. Schuller, K. B. Sloan, V. J. Stella, Phenytoin Prodrugs III Water-Soluble Prodrugs for Oral and/or Parenteral Use , J. Pharm. Sci. 1984, 73, 1068- 1073 S. A. Varia, S. Schuller, V. J. Stella, Phenytoin Prodrugs IV Hydrolysis of Various 3-(Hy-droxymethyl)phenytoin Esters , J. Pharm. Sci. 1984, 73, 1074-1080 S. A. Varia, V. J. Stella, Phenytoin Prodrugs V In vivo Evaluation of Some Water-Soluble Phenytoin Prodrugs in Dogs , J. Pharm. Sci. 1984, 73, 1080-1087. 

S. A. Varia, V. J. Stella, Phenytoin Prodrugs VI In vivo Evaluation of a Phosphate Ester Prodrug of Phenytoin after Parenteral Administration to Rats , J. Pharm. Sci. 1984, 73, 1087-1090. 

A. Khalaj, M. Amanlou, M. Jorjani, Cyclic Acetal-Like Derivatives of Diclofenac Synthesis and in vivo Evaluation , Pharm. Pharmacol. Commun. 1998, 4, 201 - 203. 

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