Vitamin D-dependent calcium-binding

Gross M, Kumar R. 1990. Physiology and biochemistry of vitamin D-dependent calcium binding proteins. Am J Physiol 259 F195-F209. 

A protein of similar molecular weight to that of rat oncomodulin, rat and rabbit parvalbumins, S100, and the vitamin D-dependent calcium-binding proteins has been isolated from chicken gizzard smooth muscle. In this case, however, the fluorescence emission from the four tyrosine residues is quenched by Ca2+ binding.(160) The decrease in fluorescence intensity was used to suggest that there are two different classes of Ca2+binding sites. 

D. M. E. Szebenyi, S. K. Obendorf, and K. Moffat, Structure of vitamin D-dependent calcium-binding protein from bovine intestine, Nature 294, 327-332 (1981). 

Darwish, H, M., Krisinger, Strom, M., and DeLuea, H. E (1987). Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine, Proc- NuiS. Aesd. Set. U,Sj4, 84,6108-6111-... 

Calcitriol behaves like a steroid hormone. It is transported to the nucleus of renal distal tubule cells, intestinal epithelial cells, osteoclasts, and osteoblasts where it induces calbindins, vitamin D-dependent calcium binding proteins. Calbindins mediate the intracellular movement of calcium, from diet to blood, from blood to osteoid matrix, or from bone to blood. There are two calbindin proteins, each encoded by separate genes, one of molecular weight about 9 kDa (calbindin-D. ) and one of molecular weight 28 kDa (calbindin-D28K). Each binds micromolar amounts of calcium and each disappears from animals that are... 

Halasz N, Hokfelt T, Norman AW, Goldstein M. 1985. Tyrosine hydroxylase and 28K vitamin D-dependent calcium binding protein are localized in different subpopulations of periglomerular cells of the rat olfactory bulb. Neurosci Lett 61 103-107. 

Jande SS, Tolnai S, Lawson DEM (1981b) Immunohistochemical localization of vitamin D-dependent calcium-binding protein in duodenum, kidney, uterus and cerebellum of chickens. Histochemistry, 71, 99-116. 

Roth J, Baetens D, Norman AW, Garcia-Segura LM (1981) Specific neurons in chick central nervous system stain with an antibody against chick intestinal vitamin D-dependent calcium-binding protein. Brain Res., 222, 452-457. 

Cavaggoni, A. Calcium regulation in cell biology. Bioscience Reports 9 (1989), 421M 36. Christakos, S., C. Gabrielides, and W. B. Rhoten. Functional considerations of vitamin-D dependent calcium binding proteins. Endocrine Rev. 10 (1989), 3-26. 

Varghese, S., and Christakos, S. (1987). A Quantitative Immunobinding Assay for Vitamin D Dependent Calcium Binding Protein (Calbindin-D28K) Using Nitrocellulose Filters, Biochem. 165 183-189. 

Dupret, J.M., Brun, P., Perret, C., et al. 1987. Transcriptional and post-transcriptional regulation of vitamin D-dependent calcium-binding protein gene expression in the rat duodenum by 1,25-dihydroxycholecalciferol. J. Biol. Ghent. 262 16553-55. 

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