Polyoma virus, oncogenes

Tmns ienic model of breast cancer. FVB mice transgenic for the polyoma virus middle T (PyVT or PyMT) oncogene under the mouse mammary tumor virus (MMTV) long terminal repeat 206 (LTR), generated as previously described (IS)., are used for in vivo invasion assays at 12-14 weeks of age when the tumors are about 2 cm in diameter see Note 2). 

Bautch, V.L., Toda, S., Hassell, J.A., and Hanahan, D., Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene. Cell, 51, 529-537, 1987. 

Taraboletti, G., Belotti, D., Dejana, E., Montovani, A., and Giavazzi, R., Endothelial cell migration and invasiveness are induced by a soluble factor produced by murine endothelioma cells transformed by polyoma virus middle T oncogene. Cancer Res., 53, 3812-3816, 1993. 

Hays, E.F. 1964. Comparative oncogenic properties of deoxyribonucleic acid from primary parotid gland tumors, passage parotid gland tumors, and polyoma virus. Cancer Res. 24 1741-1744. 

Fogel, M. and Defendi, V. (1967) Infections of muscle cultures from various species with oncogenic DNA viruses (SV40 and Polyoma). Proceedings of the National... 

Virus-specific genes and their products are directly responsible for the oncogenic action, e.g. in the case of polyoma- and adenoviruses. 

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