Tumor vascular window model

Response of Tumor Blood Vessels to Ionizing Radiation Tumor Vascular Window Model Growth Factors Contribute... 

Previous studies of tumor blood vessel response to radiation have relied upon the clearance of Xe and the quantity of RBCs (Cr-59) within tumors following treatment with radiation (3,6,8). Currently available methods allow direct, longitudinal observation of tumor blood volume and blood flow (10,11). More recent models include the tumor vascular window (11), power Doppler sonography (10), and histologic evaluation of tumor blood vessels (12,13). These models permit characterization of the dose-dependent response in tumor blood vessels. 

The dorsal skin fold window model allows direct observation of tumor microvasculature (11). This model also permits longitudinal assessment of the tumor vascular response to therapy. An accurate systematic measurement of tumor blood vessels in the window model is the linear summation of blood vessels using Optimas software. This approach corrects for vascular dilation and hemorrhage. Quantification of red... 

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