Vascular permeability, tumors

Maeda H, Wu J, Sawa T, Matsumara Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics a review. J Control Rel 2000 65 271. 

Yeo KT, Wang HH, Nagy JA, et al. Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions. Cancer Res 1993 53 2912-2918. 

Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983 219 983-985. 

Blockade of angiogenesis is useful in tumor therapy (Ferrara and Kerbel 2005 Menakuru et al. 2008). Over the last decade, the most extensively examined proan-giogenic molecule has been VEGF, a secreted protein that, through activation of tyrosine kinase receptors, promotes key events in angiogenesis that include increases in vascular permeability, and stimulation of endothelial cell proliferation and migration (Ferrara 2003). 

Yuan, F., M. Dellian, D. Fukumura, M. Leunig, D. A. Berk, V. P. Torchilin, and R. K. Jain. 1995. Vascular permeability in a human tumor xenograft molecular size dependence and cutoflsizssr Res55 3752-3756. 

The vascular endothelial growth factor is produced by tumor cells, macrophages, and endothelial and smooth muscle cells. It induces vascular endothelial cell migration, enhances vascular permeability, and promotes extravasation of plasma proteins from tumor vessels to form an extracellular matrix, facilitating inward migration of endothelial cells (Callagy et al., 2000). These characteristics impart selectivity to VEGF for endothelial cells. 

Berse B, Brown LF, Van de Water L, Dvorak HF, Senger DR. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Molecular Biology of the Cell 1992, 3, 211-220. 

Senger, D.R., Connolly, D.T., Van de Water, L., Feder, J., and Dvorak, H.F. 1990. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50 1774-1778. 

Dreher, M R., Liu, W., Michelich, C.R., Dewhirst, M.W., Yuan, F., and Chilkoti, A. (2006) Tumor vascular permeability, accumulation, and penetration of macro-molecular drag carriers. Journal of the National Cancer Institute 98 335-344. 

Brandsma D, Stalpers L, Ttial W, Sminia P, vtm den Bent MJ (2008) Clinical features, mechanisms, and management of pseudoprogression in mtiligntmt gliomas. Lancet Oncol 9 453-461 Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blackiock JB, Oldfield EH (1987) Vascular permeability induced by protein product of mtilignant brain tumors inhibition by dexamethasone. 

Potgens, A. J., Westphal, H. R., de Waal, R. M. and Ruiter, D. J. (1995). The role of vascular permeability factor and basic fibroblast growth factor in tumor angiogenesis. Biol. Chem. Hoppe Seyler 376, 57-70. 

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