Heparin-binding glycoprotein

Shackelton LM, Mann DM, Millis AJ 1995 Identification of a 38kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling. J Biol Chem 270 13076—13083... 

Like VEGF165, native VEGF is a heparin-binding homodimeric glycoprotein of 45 kDa. In contrast, VEGFi2i lacks heparin-binding properties. VEGF i89... 

Leung L Saigo K., Grant D. Heparin binds to human monocytes and modulates their procoagulant activities and secretory phenotypes. Effect of histidine-rich glycoprotein. Blood 1989 73, 177-84. 

Sung, U., O Rear, J.J. and Yurchenco, P.D. (1993) Cell and heparin-binding sites in the distal long arm of laminin identification of active and cryptic sites with recombinant and hybrid glycoprotein. J. Cell Biol. 123 1255-1268. 

Feldman SA, Hendry RM, Beeler JA. Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G. J Virol 1999 73(8) 6610-7. 

Antithrombin, already mentioned in the context of heparin, is the most abundantly occurring natural inhibitor of coagulation. It is a single-chain 432 amino acid glycoprotein displaying four oligosaccharide side chains and an approximate molecular mass of 58 kDa. It is present in plasma at concentrations of 150 pig ml 1 and is a potent inhibitor of thrombin (factor Ha), as well as of factors IXa and Xa. It inhibits thrombin by binding directly to it in a 1 1 stoichiometric complex. 

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