Vancomycin-chitosan

A porous hydroxyapatite-coated TijAl V could be prepared for the subsequent electrolytic deposition of vancomycin-chitosan compos-... 

Cevher, E., Orhan, Z., Miilazimoglu, L. et al. 2006. Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyehtis caused by methicillinresistant Staphylococcus aureus with prepared microspheres. Int J Pharm. 317 127-135. 

Khangtragool et al. studied about chitosan as an ocular drug delivery vehicle for vancomycin. Their study demonstrated quite clearly that a 0.3% w/v chitosan solution in 1% aqueous L-lactic acid offers several advantages as a vehicle for the ophthalmic delivery of vancomycin. These advantages include controlled drug delivery for the eye, biocompatibility, storage stability, and cost... 

Khangtragool, A. Ausayakhun, S. Leesawat, P Laokul, C. Molloy, R. Chitosan as an ocular drug delivery vehicle for vancomycin. J. Appl. Polym. Sci. 2011,122 (5), 3160-3167. 

Bigucci F., Luppi B., Cerchiara T, Sorrenti M., Bettinetti G., Rodriguez L., Zecchi V. (2008). Chitosan/pectin polyelectrolyte complexes Selection of suitable preparative conditions for colon-specific delivery of vancomycin. Eur. I. Pharm. Sci.. 35,435-441. 

Doty, H.L., Leedy, M.R., Courmey, H.S., Haggard, W.O., Bumgardner, J.D., 2014. Composite chitosan and calcium sulfate scaffold for dual dehvery of vancomycin and recombinant human hone morphogenetic protein-2. Journal of Materials Science Materials in Medicine 25, 1449-1459. 

Other derivatives and chitosan salts, such as chitosan lactate, chitosan aspartate, chitosan glutamate, and chitosan hydrochloride, were also shown to be good candidates for nasal sustained release of, for example, the antibiotic vancomycin hydrochloride [87]. In addition, chitosan microparticles with diphtheria toxoid (DT) for nasal administration were produced. These microparticles administration resulted in a protective systemic and local immune response against DT with enhanced IgG production. The induction of serum IgG responses were similar to secretory IgA levels, and are superior to parenteral administration of the vaccine [88]. 

T. Fang, J. Wen, J. Zhou, Z. Shao, and J. Dong, Poly (epsilon-caprolactone) coating delays vancomycin delivery from porous chitosan/beta-tricalcium phosphate composites, /. Biomed. Mater. Res. BAppl. Biomater., 100 (7), 1803-1811,2012. 

---