Vancomycin, antibiotic

Binding of bidentate sulfur ligands can also be of importance in the inhibition of zinc containing enzymes. An aminopeptidase which is essential for vancomycin antibiotic resistance in... 

Jorgensen, T. J. D., Hvelplund, P., Andersen, J. U., Roepstorff, P. Tandem mass spectrometry of specific vs. nonspecific noncovalent complexes of vancomycin antibiotics and peptide ligands. Int J Mass Spectrom 2002, 219, 659-670. Tahallah, N., Pinkse, M., Maier, C. S., Heck, A. J. The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-fiight instrument. Rapid... 

Oxidative phenolic coupling.1 The vancomycin antibiotics are polypeptides with bridging diphenyl ether groups. Evans et al. have shown in model systems such as 1 that cyclization to o-halophenolic peptides (2) can be accomplished by oxidation with thallium(III) nitrate in THF-methanol or CH2Cl2-methanol followed by CrCl2 reduction of a para-quinol intermediate (a). In three cases the yield of cyclic products was 40-48%. 

With the presented total syntheses of the vancomycin aglycon, for the first time comprehensive methods and strategies for the synthesis of vancomycin antibiotics and the construction of modified structures are available. Recently, bacterial strains have been discovered that displayed resistance against vancomycin [2]. Against this background, new biological studies with synthetically modified members of the vancomycin class of natural substances could be promising for the future. 

VANCOMYCIN ANTIBIOTICS-AMINOGLYCOSIDES, COLISTIN, TEICOPLANIN t risk of nephrotoxicity and ototoxicity Additive effect Hearing and renal function should be carefully monitored... 

The vancomycin antibiotics act by an intriguing mechanism [137,138]. They interfere with the transglycosylation step of the bacterial peptidoglycan biosynthesis. Vancomycin binds to mucopeptide precursor molecules of the bacterial cell wall, terminating in Lys-D-Ala-D-Ala [139] and thereby preventing the approach of the transglycosylase. 

Valsartan - angiotensin II inhibitor antihypertensive Vancomycin - antibiotic Venlafaxine - antidepressant... 

The client s white blood cell count does not affect the nurse s responsibility to administer the vancomycin antibiotic as soon as possible. 

Brigham RB, Pittenger RC (1956) Streptomyces orientalis, n. Sp, the source of vancomycin. Antibiot Chemother 6 642-647... 

Jorgensen, T.J.D., Hvelplund, P, Andersen, J.U., Roepstorffi P. (2002) Tandem mass spectrometry of specific vs. nonspecific noncovalent complexes of vancomycin antibiotics and peptide ligands. Int. J. Mass Spectrom., 219, 659-670. 

Fig. 10.2 Distally-bridged peptidocalixarene mimics the mode of binding of vancomycin antibiotics by binding D-Ala-D-Ala by the suggested binding mechanism (Image from Casnati et al. [4])...

Gerhard U, Mackay IP, Maplestone RA, Williams DH. The role of the sugar and chlorine suhstituents in the dimerization of vancomycin antibiotics. J. Am. Chem. Soc. 1993 115 ni-Tii. 

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