Terconazole vaginal cream

Terconazole Terazol Vaginal cream vaginal suppositories Vulvovaginal candidiasis... 

Terconazole and butoconazole nitrate (Femstat) are available as a 2% vaginal cream. They are used at bedtime for 3 d in nonpregnant females. There is a slower response during pregnancy, which requires a 6-d course of treatment. 

Terconazole and butoconazole Terconazole is a ketal triazole with structural similarities to ketoconazole. The mechanism of action of terconazole is similar to that of the imidazoles. The 80-mg vaginal suppository is inserted at bedtime for 3 days, whereas the 0.4% vaginal cream is used for 7 days, and the 0.8% cream for 3 days. Clinical efficacy and patient acceptance of both preparations are at least as good as for clotrimazole in patients with vaginal candidiasis. Butoconazole is an imidazole that is pharmacologically quite comparable to clotrimazole. 

Clotrimazole 500 mg vaginal suppository once weekly Fluconazole 100 or 150 mg orally once weekly Terconazole 0.8% cream 5 g vaginally once weekly Monthly... 

Terconazole is prepared in creams and ovules for intra-vaginal use. Besides local irritation it causes systemic reactions. Headache was reported in over a quarter of patients. Other effects include hjrpotension, fever, and chills. Terconazole is absorbed to a greater extent than other topical azoles (SED-12, 684). 

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