Butoconazole nitrate vaginal cream

The butoconazole nitrate vaginal cream, 2%, contains butoconazole nitrate 2%, an imidazole derivative with antifungal activity. Its chemical name is ( )-l-[4-(p-chlo-rophenyl)-2-[(2,6-dichlorophenyl)thio]butyl] imidazole mononitrate. It contains 2% butoconazole nitrate in a cream of edetate disodium, glyceryl monoisostearate, methylparaben, mineral oil, polyglyceryl-3 oleate, propylene 

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Terconazole and butoconazole nitrate (Femstat) are available as a 2% vaginal cream. They are used at bedtime for 3 d in nonpregnant females. There is a slower response during pregnancy, which requires a 6-d course of treatment. 

Seidman, L. S., and Skokos, C. K. (2005), An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis, Infect. Dis. Obstet. Gynecol., 13,197-206. 

Brown, D., Henzl, M. R., and Kaufman, R. H. (1999), Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group, /. Reprod. Med., 44, 933-938. 

Butoconazole nitrate (Mycelex 3, others) is available as a 2% vaginal cream it is used at bedtime in nonpregnant females. 

Butoconazple, an imidazole, is pharmacologically quite comparable to clotrimazole. Butoconazole nitrate (mycelex 3, others) is available as a 2% vaginal cream. Because of the slower response during pregnancy, a 6-day course is recommended (during the second and third trimester). 

Weinstein, L. Henzel, M.R. Tsina, I.W. Vaginal retention of 2% butoconazole nitrate cream comparison of a standard and a sustained-release preparation, Clin.Ther., 1994,16, 930-934. 

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