Ulcer bleeding

Chan FK, Hung LC, Suen BY, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl f Med 2002 347 2104-2410. 

Cyclooxygenase-1 Inhibitor Chronic (gastrointestinal system) Ulceration/ bleeding in gastrointestinal tract Naproxen29... 

Symptoms of exposure Produces skin burns. Causes eye irritation on contact. Inhalation may cause irritation of the respiratory tract. Acute toxic effects following ingestion may include corrosion of mouth and gastrointestinal tract, vomiting, diarrhea, ulceration, bleeding from intestines and circulatory collapse (Patnaik, 1992 Windholz et al., 1983). An irritation concentration of 25.00 mg/m in air was reported by Ruth (1986). 

Side-effects of corbamazepine include blood disorders such as thrombocytopenia, leucopenia, aplastic anaemia and agranulocytosis. Patients ore therefore advised to stop treatment and contact a healthcare provider if they develop symptoms of sore throat, fever, rash, mouth ulcers, bleeding or bruising. 

Dermal corrosion is the production of irreversible damage of the skin namely, visible necrosis through the epidermis and into the dermis, following the application of a test substance for up to four hours. Corrosive reactions are typified by ulcers, bleeding, bloody scabs, and, by the end of observation at 14 days, by discoloration due to blanching of the skin, complete areas of alopecia, and scars. Histopathology should be considered to evaluate questionable lesions. ... 

Ulcer bleeding. In those with peptic ulcer risks of dying are markedly raised in the elderly, in those with concomitant general disease, and where bleeding is substantial, or with combinations of these. By contrast young patients, aged under 45, with no... 

Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis proton pump inhibitor treatment for ulcer bleeding reduces transfusion requirements and hospital stay-results from the Cochrane Collaboration. Aliment Pharmacol Ther 2005 22 169-74. 

Geriatric Considerations - Summary Use of NSAIDs in older adults increases the risk of GI complications including gastric ulceration, bleeding, and perforation. These complications are not necessarily preceded by less severe GI symptoms. Concomitant use of a proton pump inhibitor or misoprostol reduces the risk for gastric ulceration and bleeding, but may not prevent long-term GI toxicity. No clinical data exist to support reduced GI toxicity with the use of diclofenac. 

Unlabeled Uses Peptic ulcer disease, active ulcer bleeding (injection), adjunct in treatment of Helicobacter pylori infecfion. 

Gastric procedures for cancer, ulcer, bleeding, or obstruction morbid obesity suppression of gastric acid secretion. 

Increased risk of infection Impaired wound healing Peptic ulceration, bleeding, and perforation Growth retardation... 

Weil J, Langman MJ, Wainwright P, Lawson DH, Rawlins M, Logan RF, Brown TP, Vessey MP, Murphy M, Colin-Jones DG. Peptic ulcer bleeding accessory risk factors and interactions with nonsteroidal antiinflammatory drugs. Gut 2000 46(1) 27-31. 

The hypothesis that Cox-2 inhibitors are less toxic than NSAIDs on the GI tract because of sparing Cox-l-dependent GI prostaglandin synthesis is born out by these data. Furthermore, data from the rofecoxib phase II and III studies have been combined in order to compare the effects of rofecoxib with those of NSAIDs on clinical outcomes relevant to GI toxicity. In this prespecified, combined analysis of the clinical development program, rofecoxib produced a significantly reduced incidence of clinical GI ulcers, bleeds, and perforations compared with the... 

Stomach, NSAIDs, asparaginase, Peptic ulcer, bleeding,... 

The risk of gastrointestinal ulceration, bleeding and even perforation with non-steroidal anti-inflammatory drug therapy is well known (Hawkey 1994 Lanas et al. 2003). The mechanisms by which these drugs cause gastro-intestinal irritation are complex (Rains-ford 1989). Deleterious effects may result from local actions, which cause injuries to the submucosal capillaries with subsequent necrosis and bleeding, or from inhibition of the formation of protective prostaglandins. 

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