Tumour-infiltrating lymphocytes

THP-1 Human monocytic leukaemia Thy 1+ Murine T cell antigen t.i.d. Ter in die (three times a day) TIL Tumour-infiltrating lymphocytes UMP Tissue inhibitors of metalloproteinase... 

IL-2-stimulated cytotoxic T cells appear even more efficacious than LAK cells in promoting tumour regression. The approach adopted here entails removal of a tumour biopsy, followed by isolation of T-lymphocytes present within the tumour. These tumour-infiltrating lymphocytes (TILs) are cytotoxic T-lymphocytes that apparently display a cell surface receptor which specifically binds the tumour antigen in question. They are thus tumour-specific cells. Further activation of these TILs by in vitro culturing in the presence of IL-2, followed by reintroduction into the patient along with IL-2, promoted partial/full tumour regression in well over 50 per cent of treated patients. 

Hussein, M. R. 2005. Tumour-infiltrating lymphocytes and melanoma tumorigenesis an... 

P22. Puri, R. K., Finbloom, D. S., Leland, P., Mostowski, H., and Siegel, J. P. Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2. Immunology 70, 492-497 (1990). 

Significant progress with ACT of cancer was achieved by the transfer of ex vivo expanded, tumour-antigen-specific T cells, isolated from tumour-infiltrating lymphocytes (TIL), into patients who have received lymphodepleting chemotherapy and high-dose IL-2-treatment. The 50% objective response rate in... 

Karja V et al. Tumour-infiltrating lymphocytes A prognostic factor of PSA-free survival in patients with local prostate carcinoma treated by radical prostatectomy. Anticancer... 

This outline is not exhaustive. For example there is an increasing awareness of the role played by infection with the human immunodeficiency virus while infiltration of the marrow with fibrous tissue or tumour cells will decrease production. In much the same way massive splenomegaly, so common in tropical Africa, sequesters significant volumes of red cells while malarial infection results in their accelerated breakdown. In some cases defects are multifactorial as in chronic lymphocytic leukaemia where infiltration decreases production, splenomegaly traps large amounts of blood while immune mechanisms lead to shortened survival or haemolysis. 

Plasmocytoma Extramedullary plasmocytic lymphoma likewise has its origin in immunoglobulin-secreting B-lymphocytes. It is also termed multiple myeloma. The condition occurs most frequently in 7 decade of life and ends fatally after 1-2 (-3) years. In the liver, there are sometimes sinusoidal and portal infiltrations of B-lym-phocytes and plasmocytic tumour cells nodular formation can also occur. Generally, however, liver involvement is found in 40% of cases. (47, 61) (s. fig. 38.12) Recently, patients with non-response or relapse after high-dose chemotherapy were treated successfully with thalidomide (starting with 200 mg daily, the dose was increased by 200 mg every two weeks until it reached 800 mg per day). (48, 56) Plasma cell leukaemia is a rare complicative variant which tends to have its own individual course. 

Despite prominent lymphocytic infiltrations in the thymus, lung, liver and kidney, homozygous LaP and LaP mice showed no chronic intestinal inflammation or tumour formation. 

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