Tumour promotion

Jahangir T et al (2006) Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. Hum Exp Toxicol 25(5) 235-242... 

Colburn, N.H. (1980). Tumour promotion and preneoplastic progression. In Slaga, T.J., Sivak, A. and Boutwell, R.K. (Eds). Carcinogenesis, Vol. 5. Modifiers of Chemical Carcinogenesis. Raven Press, New York, pp. 33-56. 

Involved in the control of cellular growth is c-fos, whose expression is transiently activated by certain growth factors and tumour promoters and may also be activated during cellular differentiation and by cAMP. In neutrophils, c-fos mRNA is expressed at low rates, but transcripts are greatly increased by fMet-Leu-Phe (2-50 nM). This expression is transient (peak-... 

Issinger OG, Martin T, Richter WW, Olson M and Fujiki H (1988) Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment. 

Haystead, T.A., et al.. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature, 337, 6202, 78, 1989. 

Boyland E. 1987. Estimation of acceptable levels of tumour promoters. BrJ Ind Med 44 422-423. 

C. L. Crowley-Weber, C. M. Payne, M. Gleason-Guzman, G. S. Watts, B. Futscher, C. N. Waltmire, C. Crowley, K. Dvorakova, C. Bernstein, M. Craven, H. Garewal and H. Bernstein, Development and molecular characterization of HCT-116 cell lines resistant to the tumour promoter and multiple stress-inducer, deoxycholate. Carcinogenesis, 2002, 23(12), 2063. 

J. D. Martinez, E. D. Stratagoules, J. M. LaRue, A. A. Powell, P. R. Gause, M. T. Craven, C. M. Payne, M. B. Powell, E. W. Gerner and D. L. Earnest, Different bile acids exhibit distinct biological effects the tumour promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation, Nutr. Cancer, 1998, 31(2), 111. 

Y. Hirose, C. V. Rao and B. S. Reddy, Modulation of inducible nitric oxide synthase expression in rat intestinal epithelial cells by colon tumour promoters, Int. J. Oncol., 2001, 18, 141. 

Logani MK, Sambuco CP, Forbes PD, Davies RE Skin-tumour promoting activity of methyl ethyl ketone peroxide—a potent lipid-peroxidizing agent. Pood Chem Toxicol 22 879-882, 1984... 

Peroxy derivatives of steroids have been isolated from both marine and terrestrial sources. They are most commonly 5a, 8a-endoperoxides with variations in the side-chains. The ergosterol peroxide 102 is the most ubiquitous endoperoxide-containing natural product and is isolated from a large number of sources. Ergosterol peroxide 102 was found to have antitumour activity against breast cancer and carcinosarcoma cell lines. A number of other steroidal endoperoxides have been reported which differ in the nature of the side-chain. Compound 103 was found to be an inhibitor of tumour promotion in mouse studies . 

Ilham, M., M. Yaday, and A. W. Norhanom. Tumour-promoting activity of plants used in Malaysian traditional medicine. Nat Prod Sci 1995 1(1) 31-42. 

Murakami, A. et al.. Possible anti-tumour promoters bi- and tetrafiavonoids from Lophira alata. Phytochemistry, 31, 2689, 1992. 

Vang, O., Wallin, H., Doehmer, J. Autrup, H. (1993) Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular cormnunication a modified assay for tumour promotion. Carcinogenesis, 14, 2365-2371 Verschueren, K. (1996) Handbook of Environmental Data on Organic Chemicals, 3rd Ed., New York, Van Nostrand Reinhold, pp. 866-873 Vitali, M., Leoni, V, Chiavarini, S. Cremisini, C. (1993) Determination of 2-ethyl-l-hexanol as contaminant in drinking water. J. Assoc, off anal. Chem. int., 76, 1133-1137... 

Vimala, S. 1999. Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br. J. Cancer 80 110-116. 

Poland A, Palen D, Glover E. 1982. Tumour promotion by TCDD in skin of HRS/J hairless mice. Nature 300 85-87. 

Other study, benign skin tumours. Benzoyl peroxide was active as a skin tumour promoter in several strains of mice. 

Vang, O., Wallin. H.. Doehmer. J. Autrup. H. (1993) Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular communication a modified assay for tumour promotion. Carcinogenesis, 14. 2365-2371... 

The category Id cyclization has also been applied to 4-aminoindoles of the type found in the indolelactam tumour promoters such as lyngbyatoxin A and pendolmycin. In a synthesis of analogues of lyngbyatoxin A the isoxazoline 8.4A was constructed as a key intermediate ]. Reductive cleavage of the isoxazoline ring generated 8.4B which was cyclized by reaction with terf-butyldimethylsilyl triflate (Entry 6, Table 8.1). The cyclization of a thioamide was a key step in the synthesis of pendolmycin[5] (Entry 7, Table 8.1). 

Flodstrom S, Ahlborg UG. 1989. Tumour promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Effects of exposure duration, administration schedule and type of diet. Chemosphere 19 779-783. 

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