Tumors natural

Anti-tumor Natural products Anoectochilus formosanus MCF-7 ... 

Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumors. Nature... 

Laske, D. W., Youle, R. J., and Oldfield, E. H. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med. 3 1362-1368, 1997. 

Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef FGGC, Masucci M, Pramanik A, Selivanova G. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature Med. 2004 10 1321-1328. 

Ramaswamy, S., et al. 2003. A molecular signature of metastasis in primary solid tumors. Nature Genet. 33 49-54. 

Firmin, J.L. and R.G. Fenwick Agropine. A major new plasmid-determined metabolite in crown gall tumors Nature 276 (1978) 842-844. 

Charles M. Perou, Therese Sorlie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffrey, Christian A. Rees, Jonathan R. Pollack, Douglas T. Ross, HUde Johnsen, Lars A. Akslen, Oystein Eluge, Alexander Pergamenschikov, Cheryl Williams, Shirley X. Zhu, Per E. Ldnning, Anne-Lise Borresen-Dale, Patrick O. Brown and David Botstein, Molecular portraits of human breast tumors, Nature, 406 (2000), 747-752. 

Robertson, D. M., and Williams, D. C. In vitro evidence of neutral 302 collagenase activity in an invasive mammalian tumor. Nature (Lond.). 

Dassie, J.R et al. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nature Biotechnology 27,839-846,2009. 

Beginning in the 1980s research directed toward the isolation of new drugs derived from natural sources identified a family of tumor inhibitory antibiotic substances characterized by novel struc tures containing a C C—C=C—C C unit as part of a nine or ten membered ring With one double bond and two triple bonds (-ene + di- + -yne) these com pounds soon became known as enediyne antibiotics The simplest member of the class is dynemian A most of the other enediynes have even more compli cated structures... 

The spatial and steric requirements for high affinity binding to protein kinase C (PKC), a macromolecule that has not yet been crystallized, were determined. Protein kinase C plays a critical role in cellular signal transduction and is in part responsible for cell differentiation. PKC was identified as the macromolecular target for the potent tumor-promoting phorbol esters (25). The natural agonists for PKC are diacylglycerols (DAG) (26). The arrows denote possible sites of interaction. 

Diacetylphloroglucinol and its homologues have been prepared and found to be inhibitors of the herpes vims (188). Syzygiol (50), a skin tumor promotion inhibitor, has been prepared from phloroglucinol (189). The first natural morphogen (cell-differentiation agent) (51) has also been identified as a phloroglucinol derivative (190). 

The streptovaricins inhibit the reverse transcriptase of some RNA oncogenic vimses that may be involved in the process of viral transformation (see Antiviral agents). The atropisostreptovaricins again have similar activities to the corresponding natural isomers. The streptovals and streptovarone exhibit gready improved activity against reverse transcriptase relative to the streptovaricins (85), but their in vitro activities were low (86). The damavaricins also inhibit reverse transcriptase (4) as well as tumor cell growth (87). 

BVdU is degraded by thymidine phosphorylase more rapidly than the natural substrate, thymidine. This rapid enzymic degradation may present a problem in its clinical use. Moreover, herpes vimses develop resistance to BVdU, apparendy because of mutant vimses that have lower thymidine kinase activity. G. D. Seade has dropped further development of BVdU because of increased animal tumor incidence induced by prolonged dosing (1). 

Fiber components are the principal energy source for colonic bacteria with a further contribution from digestive tract mucosal polysaccharides. Rate of fermentation varies with the chemical nature of the fiber components. Short-chain fatty acids generated by bacterial action are partiaUy absorbed through the colon waU and provide a supplementary energy source to the host. Therefore, dietary fiber is partiaUy caloric. The short-chain fatty acids also promote reabsorption of sodium and water from the colon and stimulate colonic blood flow and pancreatic secretions. Butyrate has added health benefits. Butyric acid is the preferred energy source for the colonocytes and has been shown to promote normal colonic epitheUal ceU differentiation. Butyric acid may inhibit colonic polyps and tumors. The relationships of intestinal microflora to health and disease have been reviewed (10). 

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