Tumors, crown gall

Leucinopine Crown Gall Tumor Tiss Levulinic acid Cured Lf ... 

NT538 Coxon, D. T., A. M. C. Davies, G. R. Fenwick, R. Self, J. L. Firmin, D. Fipkin and N. F. Janes. Agropine, a new amino acid derivative from crown gall tumors. Tetrahedron Lett 1980 21 495-498. 

A characteristic compound of some crown gall tumors. Proc Nat Acad Sci USA 1983 80 3573-3576. 

In our continuing interests in natural product discovery,40,41 ellagic acid and an extract of fruit from Melia volkensii (MP-extract) were screened for inhibition of Agrobacterium tume-faciens-md uced tumors using the potato disk assay.42 bioassay s usefu] for the examination of plant extracts and purified compounds which inhibit crown gall tumors (a plant neoplastic disease) that may have potential human anticancer activity.43,44... 

Plant tumors result from uncontrolled hormone production. Crown gall tumors, for example, are due to the infection of plant wounds by certain strains of Agrobacterium. These bacteria carry a large plasmid, the tumor-inducing, or T, plasmid, part of which is incorporated into the plant genome. This DNA encodes several genes that stimu-... 

Winans, S.C., Zhu, J., and More, M.I., Cell density-dependent gene expression by Agrobacterium tumifaciens during colonization of crown gall tumors, in Cell-Cell Signaling in Bacteria, Dunny G.M. and Winans, S.C., Eds., ASM Press, Washington, D.C., 1999, 117. 

Crown Gall Disease/Crown Gall Tumors... 

Firmin, J.L. and R.G. Fenwick W-(l,3-Dicarboxy-propyl) ornithine in crown gall tumors Phytochemistry 16 (1977) 761-762. 

Srivastava, B.I.S. DNA polymerases of normal and crown gall tumor tissue cultures of tobacco Plant Physiol. (1972) Suppl. 74. 

IDP, which is closely related to the classical sequestering agent ethylenediamine tetraacetic acid (EDTA), belongs to a group of natural products ("opines ) which can be found in crown gall tumors (ref. 11). IDP itself was found in mussels and squids where it occurred in the optically inactive meso form (ref. 12). However L-IDP is not the organic ligand of amavadin, because it does not produce amavadin when reacted with vanadylsulfate. 

Lynn, D. G., R. H. Chen, K. S. Manning, and H. N. Wood, The stmctural characterization of endogenous factors from Vinca rosea crown gall tumors that promote cell division of tobacco cells, Proc. Natl. Acad. Sci., 84, 615-619 (1987). 

---