Tumor necrosis factor receptor induced modulation

In addition to these downstream enzymatic effectors, IFs interact with receptors in the death pathway. K8 and K18 interact directly with the cytoplasmic domain of tumor necrosis factor receptor 2 (TNFR2) and attenuate TNF-induced, Jun NH(2)-terminal kinase (JNK) signaling, NFkB activation, and cell death (Gaulin et al, 2000). Modulation of cell... 

D. M. Rose, B. W. Winston, E. D. Chan, D. W. H. Riches, and P. M. Henson, Interferon-y and Transforming Growth Factor-P Modulate the Activation of Mitogen-Activated Protein Kinases and Tumor Necrosis Factor-a Production Induced by Fcg-Receptor Stimulation in Murine Macrophages, Biochemical Biophysical Research Communication, 238 (1997) 256-260. 

Endotoxin pyrogen induces fever by an indirect process. On entry into the circulatory system, endotoxin is bound to LPS-binding protein (LPB) that transports it to receptor cells in the reticuloendothelial system. The main target cells are circulating mononuclear cells, which produce proinflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-a (TNFot). These cytokines are involved in acute and chronic inflammation, induce fever, and modulate the host s response to bacterial infection. ° ... 

Modulation of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by dopamine receptor agonists and antagonists in mice. Immunol. Lett., 49,143-147. 

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