Trophoblast cells, human placental

Human OCTN2 was cloned from a human placental trophoblast cell line and human kidney (77,78). OCTN2 is expressed in skeletal muscle, kidney, lung, pancreas, small intestine, adrenal gland, thyroid, and brain (77,78). OCTN2 mediates Na+-independent transport of TEA whereas... 

Human placental lactogen (HPL) is a 22-kD protein with partial homology to growth hormone. HPL is secreted by syncytiotrophoblastic cells in choriocarcinoma and intermediate trophoblasts in a testicular trophoblastic tumor that is a counterpart to a uterine placental site trophoblastic tumor. 

This lesion, actually an exuberant, non-neoplastic physiologic hnding that frequently accompanies molar pregnancies, is composed mostly of implantation site intermediate trophoblasts. The constituent cells express human placental lactogen (hPL) and HLA-G. The Ki-67 index in an exaggerated placental site reaction is less than 10% to 15%.2 ... 

Xu et al. [76] have showed that human embryonic stem cells by treatment with bone morphogenetic protein-4 can be driven to differentiate into tro-phoblasts which have the ability to syncytialize and form confluent mono-layers. The differentiated cells express a number of trophoblast markers and secrete placental hormones and thus may provide an alternative placental model. Under the culture conditions used, however, the cells propagated poorly. 

R.S. Tuan, C.J. Moore, J.W. Brittingham, J.J. Kirwin, R.E. Akins, and M. Wong. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. J Cell Sci. 98 (Pt 3) 333-342 (1991). 

Twenty years ago, a high-affinity-binding site for uPA was demonstrated on the surface of peripheral blood monocytes and cultured cells of the human histiocytic lymphoma cell line, U937 [46]. The expression of uPAR on the cell surface of many cell types has since then been demonstrated, including a variety of neoplastic cell lines as well as nonneoplastic cells such as neutrophils, macrophages, keratinocytes, placental trophoblasts, endothelial, and smooth muscle cells [7, 33, 47-51]. The human uPAR gene has been mapped to chromosome 19ql.3 [52]. 

Figure 10.4 FcyRl in human placenta. CD64 staining of Hofbauer cells and perivascular monocyte/macrophages and dendritic cells. No staining of placental trophoblast epithelium or endothelium. See color insert.

Visvader, J. Verma, I.M. Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes. Mol. Cell. Biol., 9, 1336-1341 (1989)... 

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