Triterpenoids antiinflammatory activity

ANTITUMOR-PROMOTING AND ANTIINFLAMMATORY ACTIVITIES OF TRITERPENOIDS AND STEROLS FROM PLANTS AND FUNGI... 

Many oleane and ursane triterpenoids are reported to have interesting biological, pharmacological, and medicinal activities similar to those of retinoids and steroids. These include antiinflammatory activity, suppression of tumor promotion, suppression of immunoglobulin synthesis, protection of the liver against toxic injury, induction of collagen synthesis, and induction of differentiation in leukemia or teratocarcinoma cells [197]. 

Della Loggia, R., Tubaro, A., Sosa, S., Becker, H., Saar, St. and Isaac, O. 1994, The role of triterpenoids in the topical antiinflammatory activity of Calendula officinalis flowers , Planta Medica 60 516-520. 

Wound-healing effects of the flowers have been demonstrated in various animal tests. From in vitro and animal tests, topical antiinflammatory activity of the flowers is attributed to P-taraxasterol, ° isorhamnetic glycosides, and triterpenoidal fatty acid esters notably, faradiol monoester, which showed the same topical antiedematous activity in the Croton oil-induced edema model as indomethacin and at the same dose. ... 

Other common plant-derived triterpenoid acids, such as oleanolic and ursolic acid, exhibit weak antiinflammatory and antitumor activities, and studies have been directed at the synthesis of new analogues having increased potencies. These studies have led to the synthesis of 2-cyano-3,12-dioxoolean-l,9-dien-28-oic acid (CDDO) (54) and its methyl ester (55), which exhibit potent in vitro and in vivo antitumor activity against a wide range of tumors, including breast and pancreatic carcinomas and leukemias. ... 

Recent reviews classify triterpenoids according to chemical characteristics or biogenetic origin [3,11], but in the present review the emphasis is on activity and for this reason our classification is based only on antiinflammatory substances. 

From different species of this genus triterpenoid saponins have been isolated, together with other compounds such as lignans, coumarins, flavonoids and polyacetylenes. The saikosaponins from Bupleurum L. are considered as the major bioactive components mainly used for their antiinflammatory and antihepatotoxic activities. 

Terpenoids such as some triterpenoids and phytosterols are also present in almond and contribute to the bioactivity and functional properties of almond. Triterpenoids are believed to possess antiinflammatory, anti-human immunodeficiency virus (HIV), and anticancer activities [2] phytosterols are able to reduce total cholesterol and LDL cholesterol concentrations [52,53], Triterpenoids... 

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