Faradiol monoester

The triterpene-enriched fraction of the supercritical CO2 extract of the dried flowers of Calendula officinalis (Asteraceae) inhibited the croton oil-induced ear edema in mice. Of the identified compounds, the faradiol monoesters, lupeol, F-taraxasterol and a mixture of taraxasterol/ 5-amyrin were tested for their anti-inflammatory activity. Faradiol, obtained by hydrolysis of the extract, was the most active compound. It showed a dose-dependent effect with a potency that equals that of indomethacin at 0.14 fimol/cm2 (48% and 47% edema inhibition, respectively). The esterification of faradiol resulted in a reduction of more than 50% in the activity (only 31% inhibition was observed at 0.14 pmol/cm2), whereas 4/-taraxasterol, a C-16P dehydroxylated derivative of faradiol, was less active (47% inhibition at a dose of 0.28 pmol/cm2) [43]. 

In a bioassay-oriented fractionation of Calendula officinalis flower extracts, the most potent anti-inflammatory activity was found to he in the free triterpenes, rather than the saponins. While several active triterpenes were identified, the most active was faradiol monoester (Della Loggia et al. 1994). 

Wound-healing effects of the flowers have been demonstrated in various animal tests. From in vitro and animal tests, topical antiinflammatory activity of the flowers is attributed to P-taraxasterol, ° isorhamnetic glycosides, and triterpenoidal fatty acid esters notably, faradiol monoester, which showed the same topical antiedematous activity in the Croton oil-induced edema model as indomethacin and at the same dose. ... 

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See also in sourсe #XX -- [ ]

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