Triple-stage quadrupole mass spectrometry

High-performance liquid chromatography/triple stage quadrupole mass spectrometry (LC/MS/MS)... 

Multi-residue pesticide analysis in fruits and vegetables by LC/MS using triple stage quadrupole mass spectrometry and time of flight mass spectrometry (M. Takino, Yokogawa Analytical Systems, Japan)... 

Schweer, H., Watzer, B. and Seyberth, H. W. (1994) Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionisation triple stage quadrupole mass spectrometry. J. Chromatogr. B, 652, 221-7. 

TSQMS triple-stage quadrupole mass spectrometry... 

HoUosi, L., Bousova, K., and Godula, M. (2013) Validation of the Method for Determination of Pesticide Residues by Gas Chromatography — Triple-Stage Quadrupole Mass Spectrometry, Thermo Fisher Scientific Method 63899. Food Safety Response Center, Dreieich, Germany. 

Hsu, F.-F., and Turk, 1 1999. Structural Characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom., 10, 587-599. 

The types of tandem mass spectrometers capable of performing MS/MS experiments fall into two basic categories tandem in space and tandem in time. Tandem-in-space instruments have discrete mass analyzers for each stage of mass spectrometry examples include multisector, triple-quadru-pole, and hybrid instruments (instruments having mixed types of analyzers such as a magnetic sector and a quadrupole). Tandem-in-time instruments have only one mass analyzer where each stage of mass spectrometry takes place in the same analyzer but is separated in time via a sequence of events. Examples of this type of instrument include Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers and quadrupole ion traps, described in Chapter 3. 

Because of the advances in the gas-phase ionization of biomacromolecules, such as electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), mass spectrometry (MS) has become a powerful tool for detection, identification, and structural analysis of proteins, peptides, and polynucleotides. The molecules ionized in a gas phase by these methods are subsequently analyzed by sector, quadrupole, ion-trap, or time-of-flight mass spectrometers. In particular, the MS systems consisting of ESI and triple-stage quadrupole (ESI/TSQ) or ion-trap (IT) mass spectrometry and MALDI time-of-flight (MALDl/TOF) mass spectrometry have been most widely applied to the field of protein chemistry for the accurate determination of molecular mass of proteins and peptides, determination of amino acid sequence, identification of proteins by peptide mass databases, and analysis of posttranslational modifications such as phosphorylation and glycosylation. In general, current techniques allow detenni-... 

Liquid chromatography coupled with a photodiode array detector, electrospray ionization, collision-induced dissociation, and tandem mass spectrometry (LC-DAD/ESI-CID-tandem MS) on a triple quadrupole has been used to detect and characterize CGAs in green coffee beans [8,9]. Fragmentation in the quadrupole MS stages is different from that in the ion-trap instrument. 

Figure 7 The Q-TOF mass spectrometer. The MS(1) stage and collision region are similar in design to those found on a triple quadrupole Instrument. MS 2) is a reflecting oa-TOF design. (Reprinted with permission from Morris et al. (1996) Rapid Communications in Mass Spectrometry 10 889-896 John Wiley Sons Ltd.)...

This symbol refers to multistage MS/MS experiments designed to record product ion spectra where n is the number of product ion stages (fragment ions). For ion traps, sequential MS/MS experiments can be undertaken where n>2 whereas for a simple triple quadrupole system n = 2, -> Multiple-stage mass spectrometry. 

---