Triple-stage quadrupole

High-performance liquid chromatography/triple stage quadrupole mass spectrometry (LC/MS/MS)... 

Micromass Quatro II triple stage quadrupole fitted with an electrospray ion source for ESI MS and ESI MS/MS (MRM mode) analysis... 

Figure 1.9. Triple-stage quadrupole Quantum mass spectrometer capable of operating under enhanced resolution conditions. To reduce the chemical noise and to improve the sensitivity, the mass analyzers were oriented in an L shape rather than the conventional straight design. An additional benefit of the L shape orientation is a smaller foot print. (Courtesy of ThermoFisher Scientific.)...

Figure 1.14. MRM chromatograms of SCH 29851 (383.0. 337.0) and SCH 34117 (311.1 259.1) obtained using Sciex API 3000 (triple-stage quadrupole) and Sciex QSTAR pulsar (Q-TOF). Comparison of MRM chromatograms of SCH 29851 and SCH 34117 obtained at the LOQ (1 ng/mL) using the API 3000 mass spectrometer with those from the Q-TOF mass spectrometer indicated that the S/N ratio is at least 10-20 times better on the API 3000 mass spectrometer. However, the MRM chromatograms from the API 3000 mass spectrometer do not provide the option to further examine the MS/MS spectra whereas the full-scan MS/MS spectra from a Q-TOF based quantitative bioanalysis assay allows one to easily eliminate any questions about false-positive data. (Rephnted with permission from Yang et a ., 2001b.)...

In general, triple stage quadrupole mass spectrometer with ESI in positive ion mode is perceived as the most appropriate MS technique available at present for small—mostly basic—molecules and was used for the assay of nilotinib [112], sorafenib [115,116], lapatinib [117], sunitinib [113,114], bosutinib [88], vatalanib [119] axitinib [120], vandetanib [118] neratinib [87], and crizotinib [125], The latter assay for crizotinib was developed for preclinical experiments and does not contain... 

Among these, both LC-MS and LC-MS/MS approaches have been described using different mass analyzers operating in the positive ion mode scan such as triple stage quadrupole (TSQ) mass spectrometers [145, 194, 226, 227, 235, 239, 240, 242-247] and hybrid quadrupole-linear ion trap (LTQ) [173, 193, 218, 238, 241] mass spectrometers working in SRM mode as well as time-of-flight (TOF) [195] and hybrid quadrupole-TOF (Q-TOF) [236,237] mass spectrometers working in the MS mode. 

Figure 7. Triple-stage quadrupole mass spectrometer in operation.

Hsu, F.-F., and Turk, 1 1999. Structural Characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom., 10, 587-599. 

FIGURE 4.5 The five mass spectrometers commonly used for proteomic research, (a) ESI triple-stage quadrupole mass spectrometer (b) ESI quadrupole ion trap (QIT) mass spectrometer (c) MALDI time-of-flight mass spectrometer. 

Detector MS, Finnigan MAT TSQ 7000 triple stage quadrupole, selected reaction monitoring mode (m/z 285/257, offset -30 eV), collision gas argon at 0.27 Pa, heating capillary 250°, repeller 20 V, electrospray capillary 6 kV, electron multiplier 2.3 kV, sheath gas nitrogen at 344.7 kPa, auxiliary gas nitrogen at 5 L/min, octapole offset 5 eV... 

Multi-residue pesticide analysis in fruits and vegetables by LC/MS using triple stage quadrupole mass spectrometry and time of flight mass spectrometry (M. Takino, Yokogawa Analytical Systems, Japan)... 

LC L-column ODs semi-micro 10 mM ammonium formate pH 3.5 with 5 0% methanol MS detection SIM mode System LC/MS/MS on Micromass Quatro micro triple stage quadrupole, z spray ESI interface... 

Schweer, H., Watzer, B. and Seyberth, H. W. (1994) Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionisation triple stage quadrupole mass spectrometry. J. Chromatogr. B, 652, 221-7. 

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