Triple-stage quadrupole mass

High-performance liquid chromatography/triple stage quadrupole mass spectrometry (LC/MS/MS)... 

In general, triple stage quadrupole mass spectrometer with ESI in positive ion mode is perceived as the most appropriate MS technique available at present for small—mostly basic—molecules and was used for the assay of nilotinib [112], sorafenib [115,116], lapatinib [117], sunitinib [113,114], bosutinib [88], vatalanib [119] axitinib [120], vandetanib [118] neratinib [87], and crizotinib [125], The latter assay for crizotinib was developed for preclinical experiments and does not contain... 

Figure 7. Triple-stage quadrupole mass spectrometer in operation.

FIGURE 4.5 The five mass spectrometers commonly used for proteomic research, (a) ESI triple-stage quadrupole mass spectrometer (b) ESI quadrupole ion trap (QIT) mass spectrometer (c) MALDI time-of-flight mass spectrometer. 

Multi-residue pesticide analysis in fruits and vegetables by LC/MS using triple stage quadrupole mass spectrometry and time of flight mass spectrometry (M. Takino, Yokogawa Analytical Systems, Japan)... 

Schweer, H., Watzer, B. and Seyberth, H. W. (1994) Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionisation triple stage quadrupole mass spectrometry. J. Chromatogr. B, 652, 221-7. 

Haring, N., Salama, Z. and Jaegei H. (1988) Triple stage quadrupole mass spectrometric determination of bromocriptine in human plasma with negative ion chemical ionization. Arzneim.-Forsch., 38(D), 1529-1532. 

TSQMS triple-stage quadrupole mass spectrometry... 

HoUosi, L., Bousova, K., and Godula, M. (2013) Validation of the Method for Determination of Pesticide Residues by Gas Chromatography — Triple-Stage Quadrupole Mass Spectrometry, Thermo Fisher Scientific Method 63899. Food Safety Response Center, Dreieich, Germany. 

Figure 1.9. Triple-stage quadrupole Quantum mass spectrometer capable of operating under enhanced resolution conditions. To reduce the chemical noise and to improve the sensitivity, the mass analyzers were oriented in an L shape rather than the conventional straight design. An additional benefit of the L shape orientation is a smaller foot print. (Courtesy of ThermoFisher Scientific.)...

Figure 1.14. MRM chromatograms of SCH 29851 (383.0. 337.0) and SCH 34117 (311.1 259.1) obtained using Sciex API 3000 (triple-stage quadrupole) and Sciex QSTAR pulsar (Q-TOF). Comparison of MRM chromatograms of SCH 29851 and SCH 34117 obtained at the LOQ (1 ng/mL) using the API 3000 mass spectrometer with those from the Q-TOF mass spectrometer indicated that the S/N ratio is at least 10-20 times better on the API 3000 mass spectrometer. However, the MRM chromatograms from the API 3000 mass spectrometer do not provide the option to further examine the MS/MS spectra whereas the full-scan MS/MS spectra from a Q-TOF based quantitative bioanalysis assay allows one to easily eliminate any questions about false-positive data. (Rephnted with permission from Yang et a ., 2001b.)...

Among these, both LC-MS and LC-MS/MS approaches have been described using different mass analyzers operating in the positive ion mode scan such as triple stage quadrupole (TSQ) mass spectrometers [145, 194, 226, 227, 235, 239, 240, 242-247] and hybrid quadrupole-linear ion trap (LTQ) [173, 193, 218, 238, 241] mass spectrometers working in SRM mode as well as time-of-flight (TOF) [195] and hybrid quadrupole-TOF (Q-TOF) [236,237] mass spectrometers working in the MS mode. 

Hsu, F.-F., and Turk, 1 1999. Structural Characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom., 10, 587-599. 

Because of the advances in the gas-phase ionization of biomacromolecules, such as electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), mass spectrometry (MS) has become a powerful tool for detection, identification, and structural analysis of proteins, peptides, and polynucleotides. The molecules ionized in a gas phase by these methods are subsequently analyzed by sector, quadrupole, ion-trap, or time-of-flight mass spectrometers. In particular, the MS systems consisting of ESI and triple-stage quadrupole (ESI/TSQ) or ion-trap (IT) mass spectrometry and MALDI time-of-flight (MALDl/TOF) mass spectrometry have been most widely applied to the field of protein chemistry for the accurate determination of molecular mass of proteins and peptides, determination of amino acid sequence, identification of proteins by peptide mass databases, and analysis of posttranslational modifications such as phosphorylation and glycosylation. In general, current techniques allow detenni-... 

Fragmentation experiments such as precursor ion scans using triple-stage quadrupole and ion trap mass spectrometers methods provide insights can identify conmiOTi and characteristic product ions and allow the detection of minor ergot alkaloids not included in routine analyses today. Ion trap detection allows several fragmentations (MSn experiments) that can enhance the ability to elucidate the structures of unknown ergot alkaloid derivatives. 

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