Triple quadrupole-linear ion trap mass spectrometry

Zhang, M. Y., Pace, N., Kerns, E. H., Kleintop, T., Kagan, N., and Sakuma, T. (2005). Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies Application to structure elucidation of buspirone and one of its metabolites. J. Mass. Spectrom. 40 1017-1029. 

Ford, M.J. Kertesz, V. Van Berkel, G.J. Thin layer chro-matography/electrospray ionization triple quadrupole linear ion trap mass spectrometry system Analysis of rhodamine dyes separated on reversed phase C8 plates. J. Mass Spectrom. 2005, 40, 866-875. 

Triple Quadrupole Linear Ion Trap Mass Spectrometry Hybrid triple quadrupole linear ion trap (Q-Trap,AB Sciex, Foster City, CA) mass spectrometers provide scan functions identical to those of classical triple quadrupole (MRM, PI, and NL scanning). However, the Q-Trap also has scan functions (full MS... 

Shen Y, Han C, Jiang Y, Zhou X, Zhu Z, Lei X. Rapid quantification of four major bioactive alkaloids in Corydalis decumbens (Thunb.) Pers. by pressurised liquid extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Talanta 2011 84 1026-31. 

Yao, M., Ma, L., Humphreys, W.G., et al. (2008) Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer. Journal of Mass Spectrometry, 43, 1364-1375. 

Mauriala T, Chauret N, Oballa R, Nicoll-Griffith DA, Bateman KP. A strategy for identification of drug metabolites from dried blood spots using triple-quadrupole/ linear ion trap hybrid mass spectrometry. Rapid Commun Mass Spectrom 2005 19 1984-1992. 

Jones, E.B., Quadrupole, triple-quadrupole, and hybrid linear ion trap mass spectrometers for metabolite analysis, in Mass Spectrometry in Drug Metabolism and Pharmacokinetics, Ramanathan, R. (ed.), John Wiley Sons, Hoboken, NJ, 123, 2008. 

ETD induces a less-exothermic (i.e., more gentle ) electron-transfer reaction than ECD and its process is non-ergodic. ETD ean be performed in quadrupole ion trap mass spectrometers, whieh are widely available to the mass spectrometry eommu-nity. Several types of mass spectrometers have been configured to perform ETD experiments [59,60]. These include a hybrid ion trap (3D, a hnear multipole, or ring guide)-Fourier transform ion cyclotron resonance mass spectrometer (LTQ-FT), hybrid triple qrradrupole-linear ion trap irrstmment (QqQ-LIT), and hybrid qrradrupole time of flight (QTOF). 

For abbreviation of analyte names see Sect. Abbreviations . ACN acetonitrile, APCI atmospheric pressure chemical ionization, dial, microdialysis samples, ESI electrospray ionization, FA formic acid, iso isocratic, IT ion trap, lin range linear range, MeOH methanol, MRM multiple reaction monitoring, MS full scan mass spectrometry, n.s. not specified, OAc acetate, QqQ triple quadrupole mass spectrometer, SIM selected ion monitoring, Solv HPLC solvent, SQ single quadrupole mass spectrometer, T temperature Ratios given as v/v... 

Tandem methods for chemical measurements are now widely accepted and employed even when tandem is defined in the narrowest sense, such as two-dimensional gas chromatography or tandem mass spectrometry. Tandem or triple quadrupole MSs became commercially available in the early 1980s, and today these instruments are routine concepts as linear quadrupole analyzers or as ion traps. Tandem or sequential methods result in loss of signal current, yet noise is lost more so thus, S/N is increased. 

A recent paper compares the performances of GC-MS in SIM mode to those of GC coupled to tandem mass spectrometry (GC-MS/MS), either using an ion-trap or a triple quadrupole (Kinani et al, 2006). The ion trap was not suitable for the PASs determination due to a high LOQ (up to 40 mg/kg), lack of linearity and high variability (up to 26% of standard deviation when re-injecting a standard at a concentration of 10 mg/kg). The statistical comparison of the GC-MS method (with a single column) with the triple quadrupole results shows, in the latter case, a lower risk of false positives and negatives. However, the authors conclude that none of the tested methods is fully satisfactory from this point of view. 

---