Trimeprazine

Chemical Name N,N,(3-Trimethyl-10H-phenothiazine-10-propanamine Common Name Alimemazine 

Trade Name Manufacturer Country Year Introduced 

95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours. 

61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33  

The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, 

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The simultaneous determination of trimeprazine and methotrimeprazine in mixtures using the classical peroxyoxalate system based on the reaction between TCPO and hydrogen peroxide was used to validate the new methodology. The reaction was implemented by using the CAR technique, which increased nonlinearity in the chemical system studied by virtue of its second-order kinetic nature. In addition, both drugs exhibited a similar kinetic behavior and synergistic effects on each other, as can be inferred from the individual and combined (real and theoretical) CL-versus-time response curves. 

Table 6 Analysis of Various Trimeprazine/Methotrimeprazine Mixtures Using the Optimal Network Design...

Interestingly, penicillamine—a degradation product of penicillin and phenothiazines—the histamine H,—receptor antagonists, such as promethazine teoclate, methadilazine hydrochloride, trimeprazine tartrate are found to increase the cholesterol levels. 

Traube purine synthesis, 423 Triamcinolone, 201 Triamcinolone acetonide, 201 Triamterine, 427 Triazines, synthesis, 280 Triazolam, 368 Trichlomethiazide, 359 Trichomonas, 238 Tricyclic antidepressants, 149 Trifluoperidol, 306 Trifluoromethyl group, potentiation of biologic activity, 380 Triflupromazine, 380, 381 Trihexyphenidil, 47 Triiodothyronine, 95 Trimeprazine, 378 Trimethadione, 232 Trimethobenzamide, 110 Trimethoprim, 262 Trioxsalen, 334 Tripelenamine, 51 Triprolidine, 78 Tropinone, 5 Tropocaine, 7 Truth serum, 274... 

Tricyclics—compounds which differ from the phenothiazine antipsychotics in the ring-snbstitntion and chain characteristics— promethazine, trimeprazine, cyproheptadine,... 

Hj histamine receptor blockers can be grouped according to their chemical structures ethanolamine derivatives (diphenhydramine, clemastine) ethylenediamine derivatives (tripe-lennamine, pyrilamine) alkylamines (chloropheniramine, dexchlorpheniramine, brompheniramine) piperazines (cycUzine, meclizine, hydroxizine) phenothiazines (promethazine, trimeprazine) piperidines (cyproheptadine, diphenylpyraline) and others that do not belong to a specific chemical classification (terfenadine, astemizole). 

Trimeprazine Trimeprazine, 10-(3-dimethylamino-2-methylpropyl) phenothiazine (16.1.19), is synthesized by alkylating phenothiazine with l-dimethylamino-2-metyl-propylchloride [38]. 

Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin. A synonym of this drug is temaril. 

Phenothiazine derivatives promethazine hydrochloride trimeprazine tartrate... 

The use of ISEs with ion-selective membranes based on plasticized PVC, as well as glass pH electrodes, is limited to the analysis of aqueous solutions. On the other hand, sensors based on conducting polymer membranes are usually insoluble in organic solvents, which extends the range of possible applications. Electrosynthesized polypyrrole doped with calcion works as a Ca2+ sensor that can be applied as indicator electrode in the titration of Ca2+ with NaF in mixed solvents, such as water-methanol (1 1) and water-ethanol (1 1) [52], Another example is the use of polyaniline as indicator electrode in order to follow the acid-base precipitation titration of trimeprazine base with tartaric acid in isopropanol solution (see Procedure 5). 

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