Triglycerides effects

A. R. Dennison, M. Ball, L. J. Hands, P. C. Crowe. R. M. Watkins, and M, Kettle well. Total parenteral nutrition using conventional and medium chain triglycerides effect on liver function tests, complement, and nitrogen balance. J. Parem. Enl. Nutr.. 12 15-19, 1987... 

Zock PL, de Vries JH, de Fouw NJ, Katan BM. Positional distribution of fatty acids in dietary triglycerides effect on fasting blood lipoprotein concentrations in humans. AmJ... 

Natural fats and oils are composed principally of triglycerides, but other components may be present in minor quantities. These components may have important effects on the nature and quaHty of the oil or fat. 

Natural Ethoxylated Fats, Oils, and Waxes. Castor oil (qv) is a triglyceride high in ticinoleic esters. Ethoxylation in the presence of an alkaline catalyst to a polyoxyethylene content of 60—70 wt % yields water-soluble surfactants (Table 20). Because alkaline catalysts also effect transestenfication, ethoxylated castor oil surfactants are complex mixtures with components resulting from transesterrfication and subsequent ethoxylation at the available hydroxyl groups. The ethoxylates are pale amber Hquids of specific gravity just above 1.0 at room temperature. They are hydrophilic emulsifiers, dispersants, lubricants, and solubilizers used as textile additives and finishing agents, as well as in paper (qv) and leather (qv) manufacture. 

Diuretics, such as those of the thiazide type, have been the cornerstone of first-line antihypertensive treatments for decades. However, popularity and use have eroded as a result of increases in sudden death in patients on diuretic therapy, and unfavorable effects on blood Hpids profile, ie, increasing cholesterol and triglyceride. These effects have been impHcated as possible causes for the lack of decrease in the mortaUty rate resulting from acute MI in patients treated with a diuretic (187,240,241). However, diuretics do protect against stroke and CHF. 

Guanfacine. Guanfaciae, used ia patients having mild to moderate hypertension, can lower blood pressure 50/25 mm Hg (systoHc/diastoHc) ia hypertensive patients. Side effects such as sedation, dry mouth, and asthenia are less as compared to those of guanaben2 and clonidine. Guanfaciae reduces blood cholesterol and triglyceride and does not cause glucose iatolerance. 

Ethoxylated castor ods or ethoxylated castorwaxes are used as solubilizers of hydrophobic substances in cosmetics. Examples are Cremophor EL (ethyoxylated castor od) and Cremophor RH (40/60 ethoxylated hydrogenated castor od). Other ethoxylated triglycerides are not as effective as castor od. Ethoxylated castor od is also a good solubilizer for vitamin A palmitate (121). 

Significant increases in LDL, total cholesterol and LDL F[DL ratio No significant effect on levels of plasma cholesterol, FfDL cholesterol or triglyceride... 

The maximum changes achieved in a study were -20% total serum cholesterol, -40% serum triglycerides and +15% HDL-cholesterol [2]. However, there are considerable short- and long-term side-effects. The treatment should therefore be monitored by a doctor. 

Systemic treatment of 13-cis retinoic acid frequently leads to cheilitis and eye irritations (e.g., unspecific cornea inflammation). Also other symptoms such as headache, pruritus, alopecia, pains of joints and bone, and exostosis formation have been reported. Notably, an increase of very low density lipoproteins and triglycerides accompanied by a decrease of the high density lipoproteins has been reported in 10-20% of treated patients. Transiently, liver function markers can increase during oral retinoid therapy. Etretinate causes the side effects of 13-cis retinoid acid at lower doses. In addition to this, generalized edema and centrilobulary toxic liver cell necrosis have been observed. 

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